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ClinicalTrials.gov 5 recruiting now official registry

Richter Syndrome clinical trials

5 of 13 indexed Richter Syndrome trials are currently recruiting.

13 US clinical trials · 5 currently recruiting

Richter Syndrome is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 13 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 3 of these trials.

The research picture

Richter Syndrome has 13 registered US clinical trials, 5 of them open to new participants right now, about 38% of the total.

5
recruiting participants now
38%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: City of Hope Medical Center
Phase 17Phase 26

Active & Recent Trials

13 total, page 1 of 1

RECRUITING Phase 2 32 participants

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

Roswell Park Cancer Institute

NCT06863402

RECRUITING Phase 2 27 participants

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Mayo Clinic

NCT05388006

RECRUITING Phase 1 23 participants

Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation

City of Hope Medical Center

NCT06735664

RECRUITING Phase 2 20 participants

Lisocabtagene Maraleucel, Nivolumab and Ibrutinib for the Treatment of Richter's Transformation

City of Hope Medical Center

NCT05672173

RECRUITING Phase 2 20 participants

Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

Weill Medical College of Cornell University

NCT04679012

ACTIVE NOT RECRUITING Phase 2 69 participants

A Phase II Study of Venetoclax in Combination With Dose-adjusted EPOCH-R or R-CHOP for Patients With Richter's Syndrome

Dana-Farber Cancer Institute

NCT03054896

ACTIVE NOT RECRUITING Phase 1 55 participants

Duvelisib and Venetoclax in Relapsed or Refractory CLL or SLL or RS

Dana-Farber Cancer Institute

NCT03534323

ACTIVE NOT RECRUITING Phase 2 50 participants

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

M.D. Anderson Cancer Center

NCT02846623

ACTIVE NOT RECRUITING Phase 1 27 participants

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT03884998

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma

National Cancer Institute (NCI)

NCT03321643

ACTIVE NOT RECRUITING Phase 1 5 participants

Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome

National Heart, Lung, and Blood Institute (NHLBI)

NCT06676033

COMPLETED Phase 1 27 participants

Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation

TG Therapeutics

NCT02535286

COMPLETED Phase 1 7 participants

Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

David Bond, MD

NCT03892044

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Richter Syndrome Trial Landscape

13 indexed Richter Syndrome studies · 5 recruiting (38%).

Phase mix: 0 late (III/IV) vs 13 early (I/II).

Top sponsor: City of Hope Medical Center (3 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Richter Syndrome?

PlainTrial tracks 13 US clinical trials for Richter Syndrome, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Richter Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.