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NCT06735664 · ClinicalTrials.gov registry record · Phase 1
Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation
A Phase 1 study of Richter Syndrome and Recurrent Transformed Chronic Lymphocytic Leukemia, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
- 1
- Study location
NCT06735664 is a Phase 1 study of Richter Syndrome and Recurrent Transformed Chronic Lymphocytic Leukemia that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 23 participants, below the 30-participant average among 12 other Richter Syndrome trials with a reported enrollment target (23% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06735664, a Phase 1 study of Richter Syndrome and Recurrent Transformed Chronic Lymphocytic Leukemia, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I trial tests the safety and side effects of zanubrutinib in combination with odronextamab and how well it works in treating patients with Richter's transformation. Zanubrutinib, a tyrosine kinase inhibitor, blocks a protein called Bruton tyrosine kinase (BTK), which may help keep cancer cells from growing. Odronextamab is a bispecific monoclonal antibody that can bind to two different antigens at the same time. Odronextamab binds to CD20 found on B-cells (a type of white blood cell) and on many B-cell cancers and to CD3 on T-cells (also a type of white blood cell) and may interfere with the ability of cancer cells to grow and spread. Giving zanubrutinib in combination with odronextamab may be safe, tolerable and/or effective in treating patients with Richter's transformation.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Bone Marrow Biopsy
- PROCEDURE Computed Tomography
- PROCEDURE Biopsy
- PROCEDURE Echocardiography
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2025-08-14 |
| Est. Completion | 2027-12-13 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06735664
The ClinicalTrials.gov registry entry for NCT06735664 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 23 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 30-participant average among 12 other Richter Syndrome trials with a reported enrollment target (23% lower). The listed sponsor is City of Hope Medical Center, which has 582 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Richter Syndrome appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT06735664 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06735664 about?
NCT06735664 is a clinical study titled "Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation". This phase I trial tests the safety and side effects of zanubrutinib in combination with odronextamab and how well it works in treating patients with Richter's transformation. Zanubrutinib, a tyrosine kinase inhibitor, blocks a protein called Bruton tyrosine kinase (BTK), which may help keep cancer ...
What is the current status of trial NCT06735664?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2025-08-14. Estimated completion is 2027-12-13.
What conditions does trial NCT06735664 study?
This clinical trial studies the following conditions: Richter Syndrome, Recurrent Transformed Chronic Lymphocytic Leukemia, Refractory Transformed Chronic Lymphocytic Leukemia, Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma.
What interventions are being tested in trial NCT06735664?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Bone Marrow Biopsy (PROCEDURE), Computed Tomography (PROCEDURE), Biopsy (PROCEDURE), Echocardiography (PROCEDURE).
Who is sponsoring clinical trial NCT06735664?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06735664 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Richter Syndrome
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