Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Restless Leg Syndrome (RLS) clinical trials
3 of 3 indexed Restless Leg Syndrome (RLS) trials are currently recruiting.
Corpus placement: #5,209 of 28,707 conditions by registered trial count.
3 US clinical trials · 3 currently recruiting · #5,209 of 28,707 conditions by registered trial count
Restless Leg Syndrome (RLS): 3 US clinical trials tracked, 3 recruiting.
Restless Leg Syndrome (RLS) is the subject of 3 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. The most active sponsor is HBC Immunology, running 1 of these trials.
Enrollment posture brief
Registry condition restless-leg-syndrome-rls
OPEN 3 | RECR 100% | LATE 0 | EARLY 0 | RANK #5209 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Aortic Arch Aneurysm (100% recruiting · 5 trials)
Restless Leg Syndrome (RLS) lists 3 open slots (100% of 3 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Restless Leg Syndrome (RLS) on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Restless Leg Syndrome (RLS) is recruiting above its size-band peers.
3 of 3 indexed trials (100%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
3 total, page 1 of 1
Observe Change in Nasal Swab DRD2 Gene Expression in Restless Legs Syndrome (RLS) Patients on Prolonged Dopamine Agonist Treatment
HBC Immunology
NCT06726785
The Effect of Spinal Cord Stimulators on Restless Leg Syndrome
University of Alabama at Birmingham
NCT07179406
Peroneal Electrical Nerve Stimulation in Pregnancy for Restless Legs Syndrome
Rhode Island Hospital
NCT07144631
Phase Distribution
Phase data not available
Top Sponsors
Named interventions
Most-linked intervention names on Restless Leg Syndrome (RLS) records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Restless Leg Syndrome (RLS) trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Restless Leg Syndrome (RLS) page
3 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Restless Leg Syndrome (RLS) trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- HBC Immunology sponsors the most Restless Leg Syndrome (RLS) trials on record, review their full trial history before evaluating a specific study. See HBC Immunology's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Restless Leg Syndrome (RLS) condition card totals 3 registered trials; most-linked intervention Spinal Cord Stimulator (SCS) manipulation; top US site state Rhode Island. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.