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ClinicalTrials.gov 4 recruiting now official registry

Refractory Follicular Lymphoma clinical trials

4 of 11 indexed Refractory Follicular Lymphoma trials are currently recruiting.

11 US clinical trials · 4 currently recruiting

Refractory Follicular Lymphoma is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 4 of these trials.

The research picture

Refractory Follicular Lymphoma has 11 registered US clinical trials, 4 of them open to new participants right now, about 36% of the total.

4
recruiting participants now
36%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
4
top sponsor: National Cancer Institute (NCI)
Phase 15Phase 25Phase 31

Active & Recent Trials

11 total, page 1 of 1

RECRUITING Phase 3 612 participants

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

Epizyme

NCT04224493

RECRUITING Phase 2 40 participants

Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies

University of Washington

NCT05453396

RECRUITING Phase 2 23 participants

Brentuximab Vedotin and Bendamustine for the Treatment of Relapsed or Refractory Follicular Lymphoma

Joseph Tuscano

NCT04587687

RECRUITING Phase 2 22 participants

Pirtobrutinib and Mosunetuzumab for the Treatment of Relapsed/Refractory Grades 1-3A Follicular Lymphoma, PROMOTE-FL Trial

University of Washington

NCT06948786

ACTIVE NOT RECRUITING Phase 1 112 participants

A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies

BeOne Medicines

NCT05828589

ACTIVE NOT RECRUITING Phase 2 73 participants

Obinutuzumab With or Without Umbralisib, Lenalidomide, or Combination Chemotherapy in Treating Patients With Relapsed or Refractory Grade I-IIIa Follicular Lymphoma

National Cancer Institute (NCI)

NCT03269669

ACTIVE NOT RECRUITING Phase 1 53 participants

A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas

Fred Hutchinson Cancer Center

NCT03277729

ACTIVE NOT RECRUITING Phase 1 48 participants

Testing the Safety of the Anti-cancer Drugs Tazemetostat and Belinostat in Patients With Lymphomas That Have Resisted Treatment

National Cancer Institute (NCI)

NCT05627245

ACTIVE NOT RECRUITING Phase 2 41 participants

Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

National Cancer Institute (NCI)

NCT01849263

ACTIVE NOT RECRUITING Phase 1 39 participants

Lenalidomide and Ibrutinib in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

National Cancer Institute (NCI)

NCT01955499

ACTIVE NOT RECRUITING Phase 1 4 participants

An Early Phase Study of Venetoclax, Lenalidomide, and Rituximab/Hyaluronidase in Slow-Growing Lymphomas That Have Come Back After Treatment or Have Not Responded to Treatment

Thomas Jefferson University

NCT04447716

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Follicular Lymphoma Trial Landscape

11 indexed Refractory Follicular Lymphoma studies · 4 recruiting (36%).

Phase mix: 1 late (III/IV) vs 10 early (I/II).

Top sponsor: National Cancer Institute (NCI) (4 trials), 6 others listed. 11 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Follicular Lymphoma?

PlainTrial tracks 11 US clinical trials for Refractory Follicular Lymphoma, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Follicular Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.