Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Oral Cancer clinical trials
Every US clinical trial registered for Oral Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
18 US clinical trials · 9 currently recruiting
The research picture
Oral Cancer has 18 registered US clinical trials, 9 of them open to new participants right now — about 50% of the total.
- 9
- recruiting participants now
- 50%
- of trials open to enrollment
- 0
- in Phase 3–4 (later-stage)
- 2
- top sponsor: UNC Lineberger Comprehensive Cancer Center
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Clinical and Molecular Features of Oral Premalignancy and Oral Cancer
M.D. Anderson Cancer Center
NCT06550050
Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial
Tobias Todsen
NCT07203911
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain
New York University
NCT07095608
Microbiome in Head and Neck Squamous Cell Carcinoma
University of Colorado, Denver
NCT05837221
Enhancing Oral Cancer Awareness
Virginia Commonwealth University
NCT06682494
Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery
Medical College of Wisconsin
NCT06681935
Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue
University of Michigan
NCT02584270
Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction
Case Comprehensive Cancer Center
NCT07110142
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Case Comprehensive Cancer Center
NCT06627270
Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial
Rutgers, The State University of New Jersey
NCT04713449
Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer
Loren Mell, MD
NCT03383094
Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma
UNC Lineberger Comprehensive Cancer Center
NCT03174275
The Use of Functional Confections in Promoting Oral Health
Ohio State University
NCT01514552
Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN
UNC Lineberger Comprehensive Cancer Center
NCT03529422
Evaluations of Alcohol Warning Labels
University of Connecticut
NCT06129487
A Study of the Effects of PEITC on Oral Cells With Mutant p53
Georgetown University
NCT01790204
Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase
Duke University
NCT04905134
Cigarette Smoking and Oral Microbiota
National Cancer Institute (NCI)
NCT01862809
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Oral Cancer Trial Landscape
ClinicalTrials.gov lists 18 US studies indexed under Oral Cancer, and 9 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Oral Cancer shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Oral Cancer is led by UNC Lineberger Comprehensive Cancer Center with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 18 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Oral Cancer?
PlainTrial tracks 18 US clinical trials for Oral Cancer, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Oral Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.