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ClinicalTrials.gov 9 recruiting now official registry

Oral Cancer clinical trials

Every US clinical trial registered for Oral Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

18 US clinical trials · 9 currently recruiting

The research picture

Oral Cancer has 18 registered US clinical trials, 9 of them open to new participants right now — about 50% of the total.

9
recruiting participants now
50%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: UNC Lineberger Comprehensive Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 1,000 participants

Clinical and Molecular Features of Oral Premalignancy and Oral Cancer

M.D. Anderson Cancer Center

NCT06550050

RECRUITING NA 200 participants

Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial

Tobias Todsen

NCT07203911

RECRUITING NA 80 participants

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

New York University

NCT07095608

RECRUITING 60 participants

Microbiome in Head and Neck Squamous Cell Carcinoma

University of Colorado, Denver

NCT05837221

RECRUITING NA 60 participants

Enhancing Oral Cancer Awareness

Virginia Commonwealth University

NCT06682494

RECRUITING 40 participants

Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery

Medical College of Wisconsin

NCT06681935

RECRUITING NA 40 participants

Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue

University of Michigan

NCT02584270

RECRUITING NA 40 participants

Tongue Proactive Strengthening Exercise Program Following Partial/Hemi Glossectomy and Reconstruction

Case Comprehensive Cancer Center

NCT07110142

RECRUITING Phase 2 30 participants

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Case Comprehensive Cancer Center

NCT06627270

ACTIVE NOT RECRUITING NA 643 participants

Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial

Rutgers, The State University of New Jersey

NCT04713449

ACTIVE NOT RECRUITING Phase 2 126 participants

Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

Loren Mell, MD

NCT03383094

ACTIVE NOT RECRUITING Phase 2 39 participants

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

UNC Lineberger Comprehensive Cancer Center

NCT03174275

ACTIVE NOT RECRUITING Phase 1 36 participants

The Use of Functional Confections in Promoting Oral Health

Ohio State University

NCT01514552

ACTIVE NOT RECRUITING Phase 2 18 participants

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

UNC Lineberger Comprehensive Cancer Center

NCT03529422

COMPLETED NA 1,053 participants

Evaluations of Alcohol Warning Labels

University of Connecticut

NCT06129487

COMPLETED Phase 1 55 participants

A Study of the Effects of PEITC on Oral Cells With Mutant p53

Georgetown University

NCT01790204

COMPLETED NA 53 participants

Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase

Duke University

NCT04905134

COMPLETED 50 participants

Cigarette Smoking and Oral Microbiota

National Cancer Institute (NCI)

NCT01862809

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Oral Cancer Trial Landscape

ClinicalTrials.gov lists 18 US studies indexed under Oral Cancer, and 9 of those are currently open to recruitment — roughly 50% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Oral Cancer shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Oral Cancer is led by UNC Lineberger Comprehensive Cancer Center with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 18 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Oral Cancer?

PlainTrial tracks 18 US clinical trials for Oral Cancer, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Oral Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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