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NCT01862809 · ClinicalTrials.gov registry record
Cigarette Smoking and Oral Microbiota
A clinical trial of Lung Cancer and Oral Cancer, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT01862809: Completed study of Lung Cancer and Oral Cancer, sponsored by National Cancer Institute (NCI).
NCT01862809 is a study of Lung Cancer and Oral Cancer that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 50 participants, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01862809, a study of Lung Cancer and Oral Cancer, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Normal bacteria and other tiny organisms (the microbiota) live in the mouth and nose. They contribute to human health in many ways, including digesting food and balancing hormones. Testing samples from the mouth can show how microbiotas are related to health and disease. However, the microbiota in a person's mouth differs depending on the methods of collection and the part of the mouth that is tested. Understanding what can change the microbiota (including mouth sites, and what a person eats or smokes) will give more information on how to study oral microbiota and smoking-related cancers and other diseases. Objectives: * To see how smoking affects the microbiotas in mouth and nose. * To determine which collection method for mouth specimens should be used for studying microbiota. Eligibility: * Individuals at least 18 years of age who have been using tobacco products regularly for at least 5 years. * Individuals at least 18 years of age who have never smoked. Design: * Participants will be screened with a physical exam and medical history. * Participants will have a dental exam. They will provide a saliva sample. The dentist will take swabs from the inside of the mouth, including the tongue, tonsils, gums, and teeth. The inside of the nose will also be swabbed. * Participants will also fill out a questionnaire. It will ask about their history of smoking and consumption of alcohol, tea, and coffee. It will also ask about current medications, including antibiotics.
Primary Outcome
This was a descriptive study involving \~ 25 smokers and 25 non-smokers. We found and published in 2017 that alpha diversity was lower in smokers than in nonsmokers in the buccal mucosa, but inother sample sites, microbial diversity and compositionwere not significantly different by smoking status.
Conditions Studied
Study Locations (1)
New York
- University of Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2013-05-23 |
| Est. Completion | 2020-06-26 |
What the finished NCT01862809 record still lists
NCT01862809 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (95% lower).
The record links to 3 conditions, with Lung Cancer appearing as the primary indexed condition, and to 0 interventions.
NCT01862809 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT01862809 about?
NCT01862809 is a clinical study titled "Cigarette Smoking and Oral Microbiota". Background: \- Normal bacteria and other tiny organisms (the microbiota) live in the mouth and nose. They contribute to human health in many ways, including digesting food and balancing hormones. Testing samples from the mouth can show how microbiotas are related to health and disease. However, the...
What is the current status of trial NCT01862809?
This trial is currently completed. The enrollment target is 50 participants. The study started on 2013-05-23. Estimated completion is 2020-06-26.
What conditions does trial NCT01862809 study?
This clinical trial studies the following conditions: Lung Cancer, Oral Cancer, Microbiota.
Who is sponsoring clinical trial NCT01862809?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01862809 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lung Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01862809's enrollment target sits among peer trials
50 264th of 409 higher than 141 of 409 other Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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