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Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial
NCT07203911 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial is to improve the surgical treatment of patients with oral cancer. We will explore whether the use of surgeon performed ultrasound during these surgeries result in better tumor removal. We hypothesize that using intraoperative ultrasound to assist the resection results in more frequent clear surgical margins in oral cancer surgeries compared to standard methods. This improvement is associated with a reduced need for post-operative adjuvant therapies such as radiotherapy and reoperation, lower mortality rates, lower cancer recurrence, and enhanced quality of life for patients undergoing surgery for oral cancer. Participants will be randomized to either the control or intervention group: * Control group will receive standard treatment for oral cancer. * Intervention group will in addition to the standard treatment have surgery performed using ultrasound to guide the resection and evaluate resection margins intraoperatively. Outcomes: * Number of free surgical margins between control and intervention group. * Intraoperative surgeon assessed surgical margins compared to final histology report. * Dysphagia and quality of life questionnaires. * Recurrence rates. * Mortality rates. All participant will be followed-up at 3 months and 12 months with: * MDADI dysphagia questionnaire * EORTC head and neck cancer quality of life questionnaire * Follow-up on recurrrence and mortality.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Ultrasound imaging
- OTHER Standard Treatment
Study Locations (7)
Other
- Department of Otorhinolaryngology Head and Neck Surgery — Aarhus
- Department of Otorhinolaryngology Head and Neck Surgery and Audiology, Rigshospitalet — Copenhagen
- Istituto Nazionale Tumori of Milan — Milan
- Groote Schuur — Cape Town
- Karolinska Institute — Stockholm
California
- Stanford Otolaryngology - Head & Neck Surgery Department — Stanford
Georgia
- Emory University Hospital — Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-09-15 |
| Est. Completion | 2031-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07203911
The ClinicalTrials.gov registry entry for NCT07203911 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Tobias Todsen, which has 29 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Oral Cancer appearing as the primary indexed condition, and to 2 interventions — of which Ultrasound imaging is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07203911 reports 7 study locations spanning 3 distinct geographic areas — top geographies include Other, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07203911 about?
NCT07203911 is a clinical study titled "Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial". The goal of this clinical trial is to improve the surgical treatment of patients with oral cancer. We will explore whether the use of surgeon performed ultrasound during these surgeries result in better tumor removal. We hypothesize that using intraoperative ultrasound to assist the resection result...
What is the current status of trial NCT07203911?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2025-09-15. Estimated completion is 2031-08.
What conditions does trial NCT07203911 study?
This clinical trial studies the following conditions: Oral Cancer, Tongue Cancer, Squamous Cell Carcinoma of the Oral Cavity or Oropharynx. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07203911?
The interventions under investigation include: Ultrasound imaging (DIAGNOSTIC_TEST), Standard Treatment (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07203911?
This trial is sponsored by Tobias Todsen, which has 29 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07203911 being conducted?
This trial has 7 study locations across California, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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