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ClinicalTrials.gov 7 recruiting now early-phase tilt small index

Myelodysplastic Syndromes (MDS): early-phase trial registry

7 of 11 indexed Myelodysplastic Syndromes (MDS) trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,577 of 28,707 conditions by registered trial count.

11 US clinical trials · 7 currently recruiting · #1,577 of 28,707 conditions by registered trial count

Myelodysplastic Syndromes (MDS): 11 US clinical trials tracked, 7 recruiting.

Myelodysplastic Syndromes (MDS) is the subject of 11 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 2 of these trials.

Enrollment posture brief

Registry condition myelodysplastic-syndromes-mds

OPEN 7 | RECR 64% | LATE 2 | EARLY 7 | RANK #1577 | SPON 2

Nearest open-share peer: Advanced Melanoma (64% recruiting · 22 trials)

Acute Pancreatitis81.8%Myelodysplastic Syndrome (th…64%Acute Stroke45.5%Acquired Brain Injury36.4%Acute Lung Injury9.1%
Open-enrollment share among volume-matched conditions near Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes (MDS) lists 7 open slots (64% of 11 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Myelodysplastic Syndromes (MDS) on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Myelodysplastic Syndromes (MDS) is recruiting above its size-band peers.

    7 of 11 indexed trials (63.6%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Myelodysplastic Syndromes (MDS) research.

    Memorial Sloan Kettering Cancer Center accounts for 2 of 11 trials (18.2%). 10 distinct sponsors appear on at least one study for this condition label.

  3. Most Myelodysplastic Syndromes (MDS) trials plan to enrol fewer than 100 people.

    Median target enrolment is 80 among the 11 trials that report a genuine target (sentinel values excluded). 7 of those (63.6%) plan for fewer than 100 participants.

  4. Myelodysplastic Syndromes (MDS) research is mostly interventional.

    10 interventional and 1 observational studies make up this index (90.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 14Phase 23Phase 32

Open and recent trials

11 total, page 1 of 1

RECRUITING Phase 3 665 participants

A Study to Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

Celgene

NCT04064060

RECRUITING Phase 1 266 participants

ICP-248 in Combination With Azacitidine for the Treatment in Patients With Myeloid Malignancies

Beijing InnoCare Pharma Tech Co.

NCT06656494

RECRUITING NA 88 participants

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant

University of Nebraska

NCT04898790

RECRUITING Phase 1 80 participants

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

M.D. Anderson Cancer Center

NCT05092451

RECRUITING Phase 2 54 participants

Cord Blood Transplant in Adults With Blood Cancers

Memorial Sloan Kettering Cancer Center

NCT05884333

RECRUITING Phase 3 48 participants

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

Institut de Recherches Internationales Servier

NCT06465953

RECRUITING Early Phase 1 8 participants

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06398457

ACTIVE NOT RECRUITING 430 participants

A Study to Evaluate Treatment Patterns and Effectiveness of Luspatercept

Bristol-Myers Squibb

NCT06971185

ACTIVE NOT RECRUITING Phase 1 129 participants

A Study Evaluating Venetoclax in Combination With Azacitidine in Participants With Treatment-Naïve Higher-Risk Myelodysplastic Syndromes (MDS)

AbbVie

NCT02942290

ACTIVE NOT RECRUITING Phase 2 69 participants

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies

St. Jude Children's Research Hospital

NCT03849651

ACTIVE NOT RECRUITING Phase 2 59 participants

A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

Memorial Sloan Kettering Cancer Center

NCT04872595

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 3
Phase 3 2

Named interventions

Most-linked intervention names on Myelodysplastic Syndromes (MDS) records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Azacitidine Drug
3 trials
Cyclophosphamide Drug
3 trials
Thiotepa Drug
2 trials
Luspatercept Drug
2 trials
GCSF Drug
1 trials
Hyper fractionated total body irradiation Radiation
1 trials
Personalized rATG (P-rATG) Other
1 trials
Erythropoiesis-stimulating agent (ESA) Drug
1 trials

US sites by state

Facility locations filed on Myelodysplastic Syndromes (MDS) trials. A trial with sites in several states counts in each.

New York 6 trials
Texas 4 trials
Tennessee 3 trials
Massachusetts 3 trials
Illinois 3 trials
Pennsylvania 2 trials
Oregon 2 trials
Ohio 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Myelodysplastic Syndromes (MDS) page

11 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Myelodysplastic Syndromes (MDS) condition card totals 11 registered trials; most-linked intervention Azacitidine; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.