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Heart Failure With Reduced Ejection Fraction (HFrEF): later-stage trial registry
3 of 6 indexed Heart Failure With Reduced Ejection Fraction (HFrEF) trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #2,866 of 28,707 conditions by registered trial count.
6 US clinical trials · 3 currently recruiting · #2,866 of 28,707 conditions by registered trial count
Heart Failure With Reduced Ejection Fraction (HFrEF): 6 US clinical trials tracked, 3 recruiting.
Heart Failure With Reduced Ejection Fraction (HFrEF) is the subject of 6 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Josef Stehlik, running 1 of these trials.
Enrollment posture brief
Registry condition heart-failure-with-reduced-ejection-fraction-hfref
OPEN 3 | RECR 50% | LATE 3 | EARLY 1 | RANK #2866 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Achalasia (50% recruiting · 8 trials)
Heart Failure With Reduced Ejection Fraction (HFrEF) lists 3 open slots (50% of 6 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Failure With Reduced Ejection Fraction (HFrEF) on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure With Reduced Ejection Fraction (HFrEF) is recruiting above its size-band peers.
3 of 6 indexed trials (50%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Heart Failure With Reduced Ejection Fraction (HFrEF) research.
Josef Stehlik accounts for 1 of 6 trials (16.7%). 6 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure With Reduced Ejection Fraction (HFrEF) enrolment sits around 250 participants.
Median target enrolment is 250 among the 6 trials that report a genuine target (sentinel values excluded). 3 of those (50%) plan for fewer than 100 participants.
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Heart Failure With Reduced Ejection Fraction (HFrEF) research is mostly interventional.
6 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
6 total, page 1 of 1
Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
University of Rochester
NCT06964464
Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study
Ancora Heart
NCT04331769
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
Syed Hamza Mufarrih
NCT07053475
Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study
Occlutech International AB
NCT05136820
Developing Oral LT3 Therapy for Heart Failure - HFrEF
University of Pennsylvania
NCT04112316
The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation
Josef Stehlik
NCT05420012
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Failure With Reduced Ejection Fraction (HFrEF) records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Failure With Reduced Ejection Fraction (HFrEF) trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Failure With Reduced Ejection Fraction (HFrEF) page
6 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 3 Heart Failure With Reduced Ejection Fraction (HFrEF) trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Josef Stehlik sponsors the most Heart Failure With Reduced Ejection Fraction (HFrEF) trials on record, review their full trial history before evaluating a specific study. See Josef Stehlik's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Failure With Reduced Ejection Fraction (HFrEF) condition card totals 6 registered trials; most-linked intervention Liothyronine; top US site state Arizona. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.