Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
GERD: early-phase trial registry
7 of 16 indexed GERD trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,060 of 28,707 conditions by registered trial count.
16 US clinical trials · 7 currently recruiting · #1,060 of 28,707 conditions by registered trial count
GERD: 16 US clinical trials tracked, 7 recruiting.
GERD is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 3 of these trials.
Enrollment posture brief
Registry condition gerd
OPEN 7 | RECR 44% | LATE 1 | EARLY 4 | RANK #1060 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Acute Respiratory Distress Syndrome (44% recruiting · 32 trials)
GERD lists 7 open slots (44% of 16 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for GERD on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
GERD is recruiting below its size-band peers.
7 of 16 indexed trials (43.8%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
One sponsor concentrates GERD research.
Mayo Clinic accounts for 3 of 16 trials (18.8%). 12 distinct sponsors appear on at least one study for this condition label.
-
Typical GERD enrolment sits around 85 participants.
Median target enrolment is 85 among the 16 trials that report a genuine target (sentinel values excluded). 9 of those (56.3%) plan for fewer than 100 participants.
-
GERD research is mostly interventional.
13 interventional and 3 observational studies make up this index (81.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
16 total, page 1 of 1
Mechanisms Preventing Pharyngeal Reflux
Medical College of Wisconsin
NCT05696184
Truncal Vagotomy in Patients Undergoing Revisional Sleeve Gastrectomy to Gastric Bypass
Baylor Research Institute
NCT04901429
Mesh Vs Pledgets for Repair of Paraesophageal Hernia
David Krpata
NCT05974722
Famotidine and Antacids for Treatment of Dyspepsia
Stony Brook University
NCT06241183
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:
Medical College of Wisconsin
NCT07227506
Compassionate Use of Domperidone for Refractory Gastroparesis
Children's Mercy Hospital Kansas City
NCT04699591
The Effect of the Reflux Band™ Upper Esophageal Sphincter (UES) Assist Device on Reflux for Lung Transplant Recipients
University of Florida
NCT03886961
Long Term Outcomes of Bariatric Patients Treated With Surgery or Endoscopy
Johns Hopkins University
NCT03705416
Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
Mayo Clinic
NCT04795934
Gracie Diet for Gastroesophageal Reflux Disease
Johns Hopkins University
NCT04360252
Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma
AstraZeneca
NCT00317044
Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures
Swedish Medical Center
NCT01260935
Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH
Miromatrix Medical
NCT03735862
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
Mayo Clinic
NCT00728481
Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD?
University of North Carolina, Chapel Hill
NCT02226484
Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus
Mayo Clinic
NCT00573911
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on GERD records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on GERD trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this GERD page
16 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 7 GERD trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mayo Clinic sponsors the most GERD trials on record, review their full trial history before evaluating a specific study. See Mayo Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This GERD condition card totals 16 registered trials; most-linked intervention Esomeprazole; top US site state Wisconsin. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.