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GERD clinical trials
7 of 16 indexed GERD trials are currently recruiting.
16 US clinical trials · 7 currently recruiting
GERD is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 3 of these trials.
The research picture
GERD has 16 registered US clinical trials, 7 of them open to new participants right now, about 44% of the total.
- 7
- recruiting participants now
- 44%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Mayo Clinic
Active & Recent Trials
16 total, page 1 of 1
Mechanisms Preventing Pharyngeal Reflux
Medical College of Wisconsin
NCT05696184
Truncal Vagotomy in Patients Undergoing Revisional Sleeve Gastrectomy to Gastric Bypass
Baylor Research Institute
NCT04901429
Mesh Vs Pledgets for Repair of Paraesophageal Hernia
David Krpata
NCT05974722
Famotidine and Antacids for Treatment of Dyspepsia
Stony Brook University
NCT06241183
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:
Medical College of Wisconsin
NCT07227506
Compassionate Use of Domperidone for Refractory Gastroparesis
Children's Mercy Hospital Kansas City
NCT04699591
The Effect of the Reflux Band™ Upper Esophageal Sphincter (UES) Assist Device on Reflux for Lung Transplant Recipients
University of Florida
NCT03886961
Long Term Outcomes of Bariatric Patients Treated With Surgery or Endoscopy
Johns Hopkins University
NCT03705416
Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
Mayo Clinic
NCT04795934
Gracie Diet for Gastroesophageal Reflux Disease
Johns Hopkins University
NCT04360252
Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma
AstraZeneca
NCT00317044
Comparison of Laparoscopic Hill and Laparoscopic Nissen Anti-Reflux Procedures
Swedish Medical Center
NCT01260935
Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH
Miromatrix Medical
NCT03735862
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
Mayo Clinic
NCT00728481
Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD?
University of North Carolina, Chapel Hill
NCT02226484
Acid Reflux and Stromal Fibroblasts in Barrett's Esophagus
Mayo Clinic
NCT00573911
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the GERD Trial Landscape
16 indexed GERD studies · 7 recruiting (44%).
Phase mix: 1 late (III/IV) vs 4 early (I/II).
Top sponsor: Mayo Clinic (3 trials), 9 others listed. 16 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for GERD?
PlainTrial tracks 16 US clinical trials for GERD, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for GERD?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.