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Familial Hypercholesterolemia: full-pipeline trial registry
4 of 8 indexed Familial Hypercholesterolemia trials are currently recruiting.
Corpus placement: #2,176 of 28,707 conditions by registered trial count.
8 US clinical trials · 4 currently recruiting · #2,176 of 28,707 conditions by registered trial count
Familial Hypercholesterolemia: 8 US clinical trials tracked, 4 recruiting.
Familial Hypercholesterolemia is the subject of 8 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Essentia Health, running 1 of these trials.
Enrollment posture brief
Registry condition familial-hypercholesterolemia
OPEN 4 | RECR 50% | LATE 2 | EARLY 2 | RANK #2176 | SPON 1
Volume-matched condition peers
Nearest open-share peer: Abdominal Aortic Aneurysms (50% recruiting · 6 trials)
Familial Hypercholesterolemia lists 4 open slots (50% of 8 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Familial Hypercholesterolemia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Familial Hypercholesterolemia is recruiting above its size-band peers.
4 of 8 indexed trials (50%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Familial Hypercholesterolemia trials is spread across many organizations.
Essentia Health accounts for 1 of 8 trials (12.5%). 8 distinct sponsors appear on at least one study for this condition label.
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Typical Familial Hypercholesterolemia enrolment sits around 250 participants.
Median target enrolment is 250 among the 8 trials that report a genuine target (sentinel values excluded). 3 of those (37.5%) plan for fewer than 100 participants.
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Familial Hypercholesterolemia research is mostly interventional.
7 interventional and 1 observational studies make up this index (87.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
8 total, page 1 of 1
Atlantic Lipid Lowering Treatment Optimization Program
Atlantic Health System
NCT06439654
Comparing Direct vs Indirect Methods for Cascade Screening
University of Maryland, Baltimore
NCT05348564
2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)
Vanderbilt University Medical Center
NCT04941599
The ORIGIN-FH Study
University of Wisconsin, Madison
NCT07470723
Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH)
Essentia Health
NCT05238519
An Extension Trial of Inclisiran in Participants With Cardiovascular Disease and High Cholesterol
Novartis Pharmaceuticals
NCT03060577
A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH)
Merck Sharp & Dohme
NCT05952869
Effects of Low-density Lipoprotein (LDL) Apheresis on Inflammatory and Lipid Markers
Emory University
NCT01138371
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 2 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Familial Hypercholesterolemia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Familial Hypercholesterolemia trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Familial Hypercholesterolemia page
8 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Familial Hypercholesterolemia trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Essentia Health sponsors the most Familial Hypercholesterolemia trials on record, review their full trial history before evaluating a specific study. See Essentia Health's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Familial Hypercholesterolemia condition card totals 8 registered trials; most-linked intervention LDL Apheresis; top US site state Virginia. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.