Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression Severe: early-phase trial registry
2 of 4 indexed Depression Severe trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #4,115 of 28,707 conditions by registered trial count.
4 US clinical trials · 2 currently recruiting · #4,115 of 28,707 conditions by registered trial count
Depression Severe: 4 US clinical trials tracked, 2 recruiting.
Depression Severe is the subject of 4 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Kintsugi Mindful Wellness, running 2 of these trials.
Enrollment posture brief
Registry condition depression-severe
OPEN 2 | RECR 50% | LATE 0 | EARLY 1 | RANK #4115 | SPON 2
Volume-matched condition peers
Nearest open-share peer: Abdominal Aortic Aneurysms (50% recruiting · 6 trials)
Depression Severe lists 2 open slots (50% of 4 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression Severe on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression Severe is recruiting above its size-band peers.
2 of 4 indexed trials (50%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
Open and recent trials
4 total, page 1 of 1
Kintsugi Voice Device Pivotal Study
Kintsugi Mindful Wellness
NCT06809907
Telehealth Behavioral Activation for Teens
Baylor College of Medicine
NCT06273995
Kintsugi Voice Device Pilot Study
Kintsugi Mindful Wellness
NCT06374056
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals
NCT05686408
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression Severe records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression Severe trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression Severe page
4 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Depression Severe trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Kintsugi Mindful Wellness sponsors the most Depression Severe trials on record, review their full trial history before evaluating a specific study. See Kintsugi Mindful Wellness's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression Severe condition card totals 4 registered trials; most-linked intervention Kintsugi Voice Device; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.