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ClinicalTrials.gov 12 recruiting now official registry

Covid19 clinical trials

12 of 95 indexed Covid19 trials are currently recruiting.

95 US clinical trials · 12 currently recruiting

Covid19 is the subject of 95 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 4 of these trials.

The research picture

Covid19 has 95 registered US clinical trials, 12 of them open to new participants right now, about 13% of the total.

12
recruiting participants now
13%
of trials open to enrollment
12
in Phase 3–4 (later-stage)
4
top sponsor: Massachusetts General Hospital
Phase 110Phase 213Phase 310Phase 42

Active & Recent Trials

95 total, page 2 of 2

COMPLETED 372 participants

Asymptomatic SARS-CoV-2 Detection in Children

University of Calgary

NCT04853316

COMPLETED Phase 2 354 participants

Safety, Tolerability and Pharmacokinetics of Second Generation VIR-7831 Material in Non-hospitalized Participants With Mild to Moderate COVID-19

Vir Biotechnology

NCT04779879

COMPLETED NA 304 participants

A Follow On Community Testing Study To Evaluate The Performance of the Lucira COVID-19 All-In-One Test Kit

Lucira Health

NCT04720235

COMPLETED 300 participants

A Retrospective Study of COVID-19 Treatments

ProgenaBiome

NCT04949230

COMPLETED 297 participants

Evaluation of the INDICAID™ COVID-19 Rapid Antigen Test

University of California, Los Angeles

NCT04904510

COMPLETED NA 219 participants

Proning Early in Awake COVID-19 Hypoxic Respiratory Failure (PREACHR) Study

New York Hospital Queens

NCT05130541

COMPLETED Phase 2 181 participants

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)

BeiGene

NCT04551898

COMPLETED 167 participants

Post COVID-19 Vaccination Analysis in Healthcare Worker Recipients

Huntington Memorial Hospital

NCT04922944

COMPLETED 148 participants

Northern Colorado COVID-19 Biobank

Colorado State University

NCT04603677

COMPLETED 146 participants

Covid-19 Vaccine Responsiveness in MM and Waldenstrom

Massachusetts General Hospital

NCT04830046

COMPLETED Phase 2 142 participants

Impact of Colchicine and Low-dose Naltrexone on COVID-19

HealthPartners Institute

NCT04756128

COMPLETED 140 participants

Clinical Evaluation of a Point-of-Care (POC), COVID-19 Rapid Antigen Test (CoviDx™)

Lumos Diagnostics

NCT04750629

COMPLETED NA 136 participants

COVID-19 Project ECHO in Nursing Homes

Milton S. Hershey Medical Center

NCT04499391

COMPLETED Phase 4 110 participants

Comparing the Effects of Different Doses of Dexamethasone to Treat Inpatient COVID-19

University of Oklahoma

NCT04707534

COMPLETED Phase 1 102 participants

KBP-201 COVID-19 Vaccine Trial in Healthy Volunteers

KBio

NCT04473690

COMPLETED NA 101 participants

A Study To Evaluate The Performance of the Lucira Health All-In-One COVID-19 Test Kit vs Hologic Panther Fusion

Lucira Health

NCT04720794

COMPLETED Phase 3 98 participants

Aggrenox To Treat Acute Covid-19

Rutgers, The State University of New Jersey

NCT04410328

COMPLETED 98 participants

Evaluate Long Term Cardiovascular and Pulmonary Complications After COVID-19 With Point of Care Ultrasound

University of Louisville

NCT04756193

COMPLETED NA 92 participants

Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps

Western University of Health Sciences

NCT04928456

COMPLETED Phase 3 87 participants

Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06729593

COMPLETED 70 participants

Incidence and Predictors of Acute and Chronic Complications in Patients With Diabetes and Severe COVID-19

University of Michigan

NCT05200819

COMPLETED Phase 1 60 participants

RCT of Modified Qing Fei Pai Du Tang (mQFPD) for COVID-19

University of California, San Diego

NCT04939415

COMPLETED Phase 2 55 participants

COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications

James L. Kirkland, MD, PhD

NCT04771611

COMPLETED 50 participants

Baseline Vitamin D Deficiency and COVID-19 Disease Severity

Parkview Medical Center

NCT04628000

COMPLETED Phase 4 50 participants

Nebulized Heparin for the Treatment of COVID-19

Frederick Health

NCT04723563

COMPLETED 46 participants

Breath Analysis Based Disease Biomarkers

Mayo Clinic

NCT04341012

COMPLETED Phase 1 45 participants

REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia

Cellenkos

NCT04468971

COMPLETED NA 40 participants

Clinical Validation of New Injection Molded Flocked Nasopharyngeal Swabs in Response to the COVID-19 Pandemic

University of Virginia

NCT04368260

COMPLETED 39 participants

Blood Volume Assessment in COVID-19 and Bacterial Sepsis

NYU Langone Health

NCT04517695

COMPLETED Phase 1 35 participants

Safety and Immunogenicity Trial of an Oral SARS-CoV-2 Vaccine (VXA-CoV2-1) for Prevention of COVID-19 in Healthy Adults and Boost (VXA-CoV2-1.1-S) at 1 Year Post Initial Vaccination in Subset of Subjects

Vaxart

NCT04563702

COMPLETED Phase 1 30 participants

Transfer of Infection Fighting Immune Cells Generated in the Laboratory to High Risk Patients With COVID-19 Infection

Thomas Jefferson University

NCT04765449

COMPLETED NA 30 participants

DCI COVID-19 Surveillance Project

Temple University

NCT04780698

COMPLETED NA 30 participants

Photo-Protection Trial (NB-UVB vs. Placebo) in High-risk Hospitalized COVID-19 Patients

Cytokind

NCT04818970

COMPLETED 21 participants

Prognostic Models for COVID-19 Care

Tufts Medical Center

NCT04689711

COMPLETED Phase 2 20 participants

Evaluating Safety, Pharmacokinetics and Clinical Benefit of Silmitasertib (CX-4945) in Subjects With Moderate COVID-19

Senhwa Biosciences

NCT04663737

COMPLETED NA 20 participants

Core Warming in COVID-19 Patients Undergoing Mechanical Ventilation

Sharp HealthCare

NCT04494867

COMPLETED Phase 2 20 participants

A Trial of Aclaris Therapeutics, Inc. (ATI)-450 in Patients With Moderate-severe Novel Coronavirus Disease 2019 (COVID-19)

University of Kansas Medical Center

NCT04481685

COMPLETED Phase 1 19 participants

Electrical Stimulation for Critically Ill Covid-19 Patients

Baylor College of Medicine

NCT04685213

COMPLETED 18 participants

Performance of a Remote Monitoring Program for Patients Diagnosed With COVID-19

George Washington University

NCT05063812

COMPLETED Phase 1 15 participants

COVID-19 Study of Safety and Tolerability of Alvelestat

University of Alabama at Birmingham

NCT04539795

COMPLETED 12 participants

Cardiovascular, Pulmonary, and Integrative Functional Phenotypes in COVID-19 Survivors - Effect of Fenofibrate

University of Pennsylvania

NCT05080192

COMPLETED 12 participants

Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

Massachusetts General Hospital

NCT04476589

COMPLETED NA 6 participants

Implementation of COVID-19 Testing Strategies in Community Health Centers

Massachusetts General Hospital

NCT04802187

COMPLETED Phase 3 4 participants

Contrast Enhanced Ultrasound in COVID-19

Children's Hospital of Philadelphia

NCT04640038

COMPLETED Phase 1 3 participants

Exercise Therapy in Cancer Patients Who Are Recovering From COVID-19

Memorial Sloan Kettering Cancer Center

NCT04824443

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 13
Phase 3 10
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Covid19 Trial Landscape

95 indexed Covid19 studies · 12 recruiting (13%).

Phase mix: 12 late (III/IV) vs 23 early (I/II).

Top sponsor: Massachusetts General Hospital (4 trials), 9 others listed. 45 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Covid19?

PlainTrial tracks 95 US clinical trials for Covid19, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Covid19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.