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ClinicalTrials.gov 12 recruiting now official registry

Covid19 clinical trials

12 of 95 indexed Covid19 trials are currently recruiting.

95 US clinical trials · 12 currently recruiting

Covid19 is the subject of 95 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 4 of these trials.

The research picture

Covid19 has 95 registered US clinical trials, 12 of them open to new participants right now, about 13% of the total.

12
recruiting participants now
13%
of trials open to enrollment
12
in Phase 3–4 (later-stage)
4
top sponsor: Massachusetts General Hospital
Phase 110Phase 213Phase 310Phase 42

Active & Recent Trials

95 total, page 1 of 2

RECRUITING 27,000 participants

COVID-19 Risk Assessment for Hospitalization Outcomes and Epidemiology Efficacy

Aventyn

NCT04678193

RECRUITING 23,000 participants

Conversations You Want About Corona Virus Disease (COVID-19)

Wake Forest University Health Sciences

NCT05191420

RECRUITING 6,000 participants

COVID-19 Vaccines International Pregnancy Exposure Registry

Pregistry

NCT04705116

RECRUITING 2,000 participants

COVID-19 International Drug Pregnancy Registry

Pregistry

NCT05013632

RECRUITING 2,000 participants

KIDney Injury in Times of COVID-19 (KIDCOV)

University of California, San Francisco

NCT04705766

RECRUITING 1,500 participants

COVID-19 Survivorship Registry

NYU Langone Health

NCT04527315

RECRUITING Phase 3 820 participants

Outpatient Treatment With Anti-Coronavirus Immunoglobulin

University of Minnesota

NCT04910269

RECRUITING NA 360 participants

A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx

Albert Einstein College of Medicine

NCT04991467

RECRUITING Phase 3 240 participants

Convalescent Plasma Collection and Treatment in Pediatrics and Adults

West Virginia University

NCT04376034

RECRUITING Phase 2 80 participants

Imaging Immune Activation in COVID-19

CellSight Technologies

NCT04815096

RECRUITING Phase 2 44 participants

Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure

Jon Simmons

NCT04445285

RECRUITING Phase 2 42 participants

Defibrotide for the Treatment of Severe COVID-19

Brigham and Women's Hospital

NCT04652115

ACTIVE NOT RECRUITING 5,000 participants

Pediatric COVID Outcomes Study (PECOS)

Children's National Research Institute

NCT04830852

ACTIVE NOT RECRUITING NA 4,476 participants

Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks

University of Pennsylvania

NCT04779827

ACTIVE NOT RECRUITING 964 participants

Risk Stratification of COVID-19 Using Urine Biomarkers

National Center for Global Health and Medicine, Japan

NCT04681040

ACTIVE NOT RECRUITING NA 545 participants

Community Developed Technology-Based Messaging to Increase COVID-19 Vaccine Uptake Among People Who Inject Drugs

NDRI-USA

NCT04924803

ACTIVE NOT RECRUITING 500 participants

Post Acute Sequelae of COVID-19

Vanderbilt University Medical Center

NCT04964115

ACTIVE NOT RECRUITING Phase 2 171 participants

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

Milton S. Hershey Medical Center

NCT04802408

ACTIVE NOT RECRUITING Phase 2 150 participants

Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes

Massachusetts General Hospital

NCT02081326

ACTIVE NOT RECRUITING Phase 2 80 participants

COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation

Mayo Clinic

NCT04476953

ACTIVE NOT RECRUITING 60 participants

High Resolution Micro OCT Imaging

University of Alabama at Birmingham

NCT03256773

ACTIVE NOT RECRUITING Phase 2 60 participants

A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults

Restorbio

NCT04584710

ACTIVE NOT RECRUITING 35 participants

REsearching Covid-19 Outcomes in Diabetes (RECODE)

AdventHealth Translational Research Institute

NCT04805970

ACTIVE NOT RECRUITING Early Phase 1 20 participants

Proof-of-Concept Clinical Pharmacology Trial for COVID-19 Antigen Presentation Therapeutic Biologic Mix

Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair

NCT03305341

ACTIVE NOT RECRUITING Phase 1 20 participants

Hyperpolarized 129Xe MRI of Survivors of COVID-19

University of Kansas Medical Center

NCT04659707

COMPLETED 54,689 participants

COVID-19 Citizen Science Expansion Project

University of California, San Francisco

NCT05548803

COMPLETED Phase 3 33,000 participants

A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2

Novavax

NCT04611802

COMPLETED NA 32,750 participants

Communities Fighting COVID-19!

San Diego State University

NCT05148936

COMPLETED 14,835 participants

The PAWS-COVID-19 (Pediatric AirWay complicationS COVID-19) Registry

Boston Children's Hospital

NCT04449042

COMPLETED NA 8,519 participants

A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls

Beth Israel Deaconess Medical Center

NCT04498442

COMPLETED NA 4,733 participants

Test to Stay in School: COVID-19 Testing Following Exposure in School Communities

Duke University

NCT05052580

COMPLETED NA 3,671 participants

Use of Construal Level Theory to Inform Messaging to Increase Vaccination Against COVID-19

Brigham and Women's Hospital

NCT04871776

COMPLETED 3,402 participants

Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19

University of Michigan

NCT04706533

COMPLETED Phase 3 3,214 participants

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)

Susanna Naggie, MD

NCT06042855

COMPLETED 1,800 participants

Real World Study of COVID-19 in a Flyover Region

Tulane University

NCT04962347

COMPLETED NA 1,765 participants

A Smartphone Intervention for Relational and Mental Well Being

University of Washington

NCT04629755

COMPLETED NA 1,722 participants

Equitable Access to COVID-19 Vaccines

Mayo Clinic

NCT04952376

COMPLETED Phase 3 1,323 participants

COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)

University of Minnesota

NCT04510194

COMPLETED Phase 3 1,208 participants

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)

Susanna Naggie, MD

NCT05894564

COMPLETED NA 1,200 participants

Social Activity, Loneliness and Stigma During COVID-19 Outbreak

Columbia University

NCT04734171

COMPLETED NA 1,143 participants

Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic

Washington University School of Medicine

NCT04565509

COMPLETED NA 877 participants

Vitamin D3 Supplementation to Prevent Respiratory Tract Infections

The Cooper Health System

NCT04596657

COMPLETED NA 820 participants

The Doctors for Coronavirus Prevention Project Thanksgiving / Christmas Messaging Campaign

National Bureau of Economic Research

NCT04644328

COMPLETED NA 756 participants

Views on COVID-19 and Vaccination

University of Massachusetts, Worcester

NCT04706403

COMPLETED 704 participants

Prophylactic Versus Therapeutic Dose Anticoagulation In COVID-19 Infection at the Time of Admission To Critical Care Units

Corewell Health East

NCT04829552

COMPLETED NA 561 participants

Minnesota COVID-19 Testing Project

Harvard University

NCT04568889

COMPLETED Phase 3 511 participants

Convalescent Plasma in Outpatients With COVID-19

Stanford University

NCT04355767

COMPLETED 507 participants

COVID-19 IgG Formation in Physicians at ALGH and Their Household Members

Wake Forest University Health Sciences

NCT04540484

COMPLETED NA 412 participants

COVID-19 SAFE Enrollment

University of Pennsylvania

NCT04506268

COMPLETED NA 384 participants

Lung Ultrasound Implementation in the Management of Patients Hospitalized With COVID-19

University of Colorado, Denver

NCT04542421

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 13
Phase 3 10
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Covid19 Trial Landscape

95 indexed Covid19 studies · 12 recruiting (13%).

Phase mix: 12 late (III/IV) vs 23 early (I/II).

Top sponsor: Massachusetts General Hospital (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Covid19?

PlainTrial tracks 95 US clinical trials for Covid19, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Covid19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.