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Covid19 clinical trials
12 of 95 indexed Covid19 trials are currently recruiting.
95 US clinical trials · 12 currently recruiting
Covid19 is the subject of 95 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 4 of these trials.
The research picture
Covid19 has 95 registered US clinical trials, 12 of them open to new participants right now, about 13% of the total.
- 12
- recruiting participants now
- 13%
- of trials open to enrollment
- 12
- in Phase 3–4 (later-stage)
- 4
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
95 total, page 1 of 2
COVID-19 Risk Assessment for Hospitalization Outcomes and Epidemiology Efficacy
Aventyn
NCT04678193
Conversations You Want About Corona Virus Disease (COVID-19)
Wake Forest University Health Sciences
NCT05191420
COVID-19 Vaccines International Pregnancy Exposure Registry
Pregistry
NCT04705116
COVID-19 International Drug Pregnancy Registry
Pregistry
NCT05013632
KIDney Injury in Times of COVID-19 (KIDCOV)
University of California, San Francisco
NCT04705766
COVID-19 Survivorship Registry
NYU Langone Health
NCT04527315
Outpatient Treatment With Anti-Coronavirus Immunoglobulin
University of Minnesota
NCT04910269
A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx
Albert Einstein College of Medicine
NCT04991467
Convalescent Plasma Collection and Treatment in Pediatrics and Adults
West Virginia University
NCT04376034
Imaging Immune Activation in COVID-19
CellSight Technologies
NCT04815096
Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure
Jon Simmons
NCT04445285
Defibrotide for the Treatment of Severe COVID-19
Brigham and Women's Hospital
NCT04652115
Pediatric COVID Outcomes Study (PECOS)
Children's National Research Institute
NCT04830852
Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks
University of Pennsylvania
NCT04779827
Risk Stratification of COVID-19 Using Urine Biomarkers
National Center for Global Health and Medicine, Japan
NCT04681040
Community Developed Technology-Based Messaging to Increase COVID-19 Vaccine Uptake Among People Who Inject Drugs
NDRI-USA
NCT04924803
Post Acute Sequelae of COVID-19
Vanderbilt University Medical Center
NCT04964115
SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial
Milton S. Hershey Medical Center
NCT04802408
Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes
Massachusetts General Hospital
NCT02081326
COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation
Mayo Clinic
NCT04476953
High Resolution Micro OCT Imaging
University of Alabama at Birmingham
NCT03256773
A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults
Restorbio
NCT04584710
REsearching Covid-19 Outcomes in Diabetes (RECODE)
AdventHealth Translational Research Institute
NCT04805970
Proof-of-Concept Clinical Pharmacology Trial for COVID-19 Antigen Presentation Therapeutic Biologic Mix
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
NCT03305341
Hyperpolarized 129Xe MRI of Survivors of COVID-19
University of Kansas Medical Center
NCT04659707
COVID-19 Citizen Science Expansion Project
University of California, San Francisco
NCT05548803
A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2
Novavax
NCT04611802
Communities Fighting COVID-19!
San Diego State University
NCT05148936
The PAWS-COVID-19 (Pediatric AirWay complicationS COVID-19) Registry
Boston Children's Hospital
NCT04449042
A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls
Beth Israel Deaconess Medical Center
NCT04498442
Test to Stay in School: COVID-19 Testing Following Exposure in School Communities
Duke University
NCT05052580
Use of Construal Level Theory to Inform Messaging to Increase Vaccination Against COVID-19
Brigham and Women's Hospital
NCT04871776
Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19
University of Michigan
NCT04706533
ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)
Susanna Naggie, MD
NCT06042855
Real World Study of COVID-19 in a Flyover Region
Tulane University
NCT04962347
A Smartphone Intervention for Relational and Mental Well Being
University of Washington
NCT04629755
Equitable Access to COVID-19 Vaccines
Mayo Clinic
NCT04952376
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)
University of Minnesota
NCT04510194
ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)
Susanna Naggie, MD
NCT05894564
Social Activity, Loneliness and Stigma During COVID-19 Outbreak
Columbia University
NCT04734171
Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic
Washington University School of Medicine
NCT04565509
Vitamin D3 Supplementation to Prevent Respiratory Tract Infections
The Cooper Health System
NCT04596657
The Doctors for Coronavirus Prevention Project Thanksgiving / Christmas Messaging Campaign
National Bureau of Economic Research
NCT04644328
Views on COVID-19 and Vaccination
University of Massachusetts, Worcester
NCT04706403
Prophylactic Versus Therapeutic Dose Anticoagulation In COVID-19 Infection at the Time of Admission To Critical Care Units
Corewell Health East
NCT04829552
Minnesota COVID-19 Testing Project
Harvard University
NCT04568889
Convalescent Plasma in Outpatients With COVID-19
Stanford University
NCT04355767
COVID-19 IgG Formation in Physicians at ALGH and Their Household Members
Wake Forest University Health Sciences
NCT04540484
COVID-19 SAFE Enrollment
University of Pennsylvania
NCT04506268
Lung Ultrasound Implementation in the Management of Patients Hospitalized With COVID-19
University of Colorado, Denver
NCT04542421
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 13 |
| Phase 3 | 10 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Covid19 Trial Landscape
95 indexed Covid19 studies · 12 recruiting (13%).
Phase mix: 12 late (III/IV) vs 23 early (I/II).
Top sponsor: Massachusetts General Hospital (4 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Covid19?
PlainTrial tracks 95 US clinical trials for Covid19, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Covid19?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.