Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Covid19

Open-data reference.

90 US clinical trials · 11 currently recruiting

Active & Recent Trials

RECRUITING 27,000 participants

COVID-19 Risk Assessment for Hospitalization Outcomes and Epidemiology Efficacy

Aventyn

NCT04678193

RECRUITING 23,000 participants

Conversations You Want About Corona Virus Disease (COVID-19)

Wake Forest University Health Sciences

NCT05191420

RECRUITING 6,000 participants

COVID-19 Vaccines International Pregnancy Exposure Registry

Pregistry

NCT04705116

RECRUITING 2,000 participants

COVID-19 International Drug Pregnancy Registry

Pregistry

NCT05013632

RECRUITING 2,000 participants

KIDney Injury in Times of COVID-19 (KIDCOV)

University of California, San Francis

NCT04705766

RECRUITING 1,500 participants

COVID-19 Survivorship Registry

NYU Langone Health

NCT04527315

RECRUITING Phase 3 820 participants

Outpatient Treatment With Anti-Coronavirus Immunoglobulin

University of Minnesota

NCT04910269

RECRUITING NA 360 participants

A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx

Albert Einstein College of Medicine

NCT04991467

RECRUITING Phase 2 80 participants

Imaging Immune Activation in COVID-19

CellSight Technologies

NCT04815096

RECRUITING Phase 2 44 participants

Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure

Jon Simmons

NCT04445285

RECRUITING Phase 2 42 participants

Defibrotide for the Treatment of Severe COVID-19

Brigham and Women's Hospital

NCT04652115

ACTIVE NOT RECRUITING 5,000 participants

Pediatric COVID Outcomes Study (PECOS)

Children's National Research Institute

NCT04830852

ACTIVE NOT RECRUITING NA 4,476 participants

Improving Health Equity for COVID-19 Vaccination for At-risk Populations Using Online Social Networks

University of Pennsylvania

NCT04779827

ACTIVE NOT RECRUITING 964 participants

Risk Stratification of COVID-19 Using Urine Biomarkers

National Center for Global Health and Medicine, Japan

NCT04681040

ACTIVE NOT RECRUITING NA 545 participants

Community Developed Technology-Based Messaging to Increase COVID-19 Vaccine Uptake Among People Who Inject Drugs

NDRI-USA

NCT04924803

ACTIVE NOT RECRUITING 500 participants

Post Acute Sequelae of COVID-19

Vanderbilt University Medical Center

NCT04964115

ACTIVE NOT RECRUITING Phase 2 171 participants

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

Milton S. Hershey Medical Center

NCT04802408

ACTIVE NOT RECRUITING Phase 2 150 participants

Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes

Massachusetts General Hospital

NCT02081326

ACTIVE NOT RECRUITING Phase 2 80 participants

COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation

Mayo Clinic

NCT04476953

ACTIVE NOT RECRUITING 60 participants

High Resolution Micro OCT Imaging

University of Alabama at Birmingham

NCT03256773

ACTIVE NOT RECRUITING Phase 2 60 participants

A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults

Restorbio

NCT04584710

ACTIVE NOT RECRUITING 35 participants

REsearching Covid-19 Outcomes in Diabetes (RECODE)

AdventHealth Translational Research Institute

NCT04805970

ACTIVE NOT RECRUITING Early Phase 1 20 participants

Proof-of-Concept Clinical Pharmacology Trial for COVID-19 Antigen Presentation Therapeutic Biologic Mix

Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair

NCT03305341

ACTIVE NOT RECRUITING Phase 1 20 participants

Hyperpolarized 129Xe MRI of Survivors of COVID-19

University of Kansas Medical Center

NCT04659707

COMPLETED 54,689 participants

COVID-19 Citizen Science Expansion Project

University of California, San Francis

NCT05548803

COMPLETED Phase 3 33,000 participants

A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2

Novavax

NCT04611802

COMPLETED NA 32,750 participants

Communities Fighting COVID-19!

San Diego State University

NCT05148936

COMPLETED NA 8,519 participants

A Study on Prevalence, Protection and Recovery From COVID-19 in Seasoned Yoga Practitioners in Comparison to Age and Gender Matched Controls

Beth Israel Deaconess Medical Center

NCT04498442

COMPLETED NA 4,733 participants

Test to Stay in School: COVID-19 Testing Following Exposure in School Communities

Duke University

NCT05052580

COMPLETED NA 3,671 participants

Use of Construal Level Theory to Inform Messaging to Increase Vaccination Against COVID-19

Brigham and Women's Hospital

NCT04871776

COMPLETED 3,402 participants

Michigan Medicine COVID-19 Cohort: Clinical Characteristics, Inflammatory Markers and Outcomes of Patients Hospitalized for COVID-19

University of Michigan

NCT04706533

COMPLETED Phase 3 3,214 participants

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)

Susanna Naggie, MD

NCT06042855

COMPLETED 1,800 participants

Real World Study of COVID-19 in a Flyover Region

Tulane University

NCT04962347

COMPLETED NA 1,765 participants

A Smartphone Intervention for Relational and Mental Well Being

University of Washington

NCT04629755

COMPLETED NA 1,722 participants

Equitable Access to COVID-19 Vaccines

Mayo Clinic

NCT04952376

COMPLETED Phase 3 1,323 participants

COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)

University of Minnesota

NCT04510194

COMPLETED Phase 3 1,208 participants

ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)

Susanna Naggie, MD

NCT05894564

COMPLETED NA 1,200 participants

Social Activity, Loneliness and Stigma During COVID-19 Outbreak

Columbia University

NCT04734171

COMPLETED NA 1,143 participants

Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic

Washington University School of Medicine

NCT04565509

COMPLETED NA 877 participants

Vitamin D3 Supplementation to Prevent Respiratory Tract Infections

The Cooper Health System

NCT04596657

COMPLETED NA 820 participants

The Doctors for Coronavirus Prevention Project Thanksgiving / Christmas Messaging Campaign

National Bureau of Economic Research

NCT04644328

COMPLETED NA 756 participants

Views on COVID-19 and Vaccination

University of Massachusetts, Worcester

NCT04706403

COMPLETED 704 participants

Prophylactic Versus Therapeutic Dose Anticoagulation In COVID-19 Infection at the Time of Admission To Critical Care Units

Corewell Health East

NCT04829552

COMPLETED NA 561 participants

Minnesota COVID-19 Testing Project

Harvard University

NCT04568889

COMPLETED Phase 3 511 participants

Convalescent Plasma in Outpatients With COVID-19

Stanford University

NCT04355767

COMPLETED 507 participants

COVID-19 IgG Formation in Physicians at ALGH and Their Household Members

Wake Forest University Health Sciences

NCT04540484

COMPLETED NA 412 participants

COVID-19 SAFE Enrollment

University of Pennsylvania

NCT04506268

COMPLETED NA 384 participants

Lung Ultrasound Implementation in the Management of Patients Hospitalized With COVID-19

University of Colorado, Denver

NCT04542421

COMPLETED 372 participants

Asymptomatic SARS-CoV-2 Detection in Children

University of Calgary

NCT04853316

COMPLETED Phase 2 354 participants

Safety, Tolerability and Pharmacokinetics of Second Generation VIR-7831 Material in Non-hospitalized Participants With Mild to Moderate COVID-19

Vir Biotechnology

NCT04779879

COMPLETED NA 304 participants

A Follow On Community Testing Study To Evaluate The Performance of the Lucira COVID-19 All-In-One Test Kit

Lucira Health

NCT04720235

COMPLETED 300 participants

A Retrospective Study of COVID-19 Treatments

ProgenaBiome

NCT04949230

COMPLETED 297 participants

Evaluation of the INDICAID™ COVID-19 Rapid Antigen Test

University of California, Los Angeles

NCT04904510

COMPLETED NA 219 participants

Proning Early in Awake COVID-19 Hypoxic Respiratory Failure (PREACHR) Study

New York Hospital Queens

NCT05130541

COMPLETED Phase 2 181 participants

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19)

BeiGene

NCT04551898

COMPLETED 167 participants

Post COVID-19 Vaccination Analysis in Healthcare Worker Recipients

Huntington Memorial Hospital

NCT04922944

COMPLETED 148 participants

Northern Colorado COVID-19 Biobank

Colorado State University

NCT04603677

COMPLETED 146 participants

Covid-19 Vaccine Responsiveness in MM and Waldenstrom

Massachusetts General Hospital

NCT04830046

COMPLETED Phase 2 142 participants

Impact of Colchicine and Low-dose Naltrexone on COVID-19

HealthPartners Institute

NCT04756128

COMPLETED 140 participants

Clinical Evaluation of a Point-of-Care (POC), COVID-19 Rapid Antigen Test (CoviDx™)

Lumos Diagnostics

NCT04750629

COMPLETED NA 136 participants

COVID-19 Project ECHO in Nursing Homes

Milton S. Hershey Medical Center

NCT04499391

COMPLETED Phase 4 110 participants

Comparing the Effects of Different Doses of Dexamethasone to Treat Inpatient COVID-19

University of Oklahoma

NCT04707534

COMPLETED Phase 1 102 participants

KBP-201 COVID-19 Vaccine Trial in Healthy Volunteers

KBio

NCT04473690

COMPLETED NA 101 participants

A Study To Evaluate The Performance of the Lucira Health All-In-One COVID-19 Test Kit vs Hologic Panther Fusion

Lucira Health

NCT04720794

COMPLETED Phase 3 98 participants

Aggrenox To Treat Acute Covid-19

Rutgers, The State University of New Jersey

NCT04410328

COMPLETED 98 participants

Evaluate Long Term Cardiovascular and Pulmonary Complications After COVID-19 With Point of Care Ultrasound

University of Louisville

NCT04756193

COMPLETED NA 92 participants

Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps

Western University of Health Sciences

NCT04928456

COMPLETED Phase 3 87 participants

Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT06729593

COMPLETED 70 participants

Incidence and Predictors of Acute and Chronic Complications in Patients With Diabetes and Severe COVID-19

University of Michigan

NCT05200819

COMPLETED Phase 1 60 participants

RCT of Modified Qing Fei Pai Du Tang (mQFPD) for COVID-19

University of California, San Diego

NCT04939415

COMPLETED Phase 2 55 participants

COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications

James L. Kirkland, MD, PhD

NCT04771611

COMPLETED 50 participants

Baseline Vitamin D Deficiency and COVID-19 Disease Severity

Parkview Medical Center

NCT04628000

COMPLETED Phase 4 50 participants

Nebulized Heparin for the Treatment of COVID-19

Frederick Health

NCT04723563

COMPLETED 39 participants

Blood Volume Assessment in COVID-19 and Bacterial Sepsis

NYU Langone Health

NCT04517695

COMPLETED Phase 1 35 participants

Safety and Immunogenicity Trial of an Oral SARS-CoV-2 Vaccine (VXA-CoV2-1) for Prevention of COVID-19 in Healthy Adults and Boost (VXA-CoV2-1.1-S) at 1 Year Post Initial Vaccination in Subset of Subjects

Vaxart

NCT04563702

COMPLETED Phase 1 30 participants

Transfer of Infection Fighting Immune Cells Generated in the Laboratory to High Risk Patients With COVID-19 Infection

Thomas Jefferson University

NCT04765449

COMPLETED NA 30 participants

DCI COVID-19 Surveillance Project

Temple University

NCT04780698

COMPLETED NA 30 participants

Photo-Protection Trial (NB-UVB vs. Placebo) in High-risk Hospitalized COVID-19 Patients

Cytokind

NCT04818970

COMPLETED 21 participants

Prognostic Models for COVID-19 Care

Tufts Medical Center

NCT04689711

COMPLETED Phase 2 20 participants

Evaluating Safety, Pharmacokinetics and Clinical Benefit of Silmitasertib (CX-4945) in Subjects With Moderate COVID-19

Senhwa Biosciences

NCT04663737

COMPLETED NA 20 participants

Core Warming in COVID-19 Patients Undergoing Mechanical Ventilation

Sharp HealthCare

NCT04494867

COMPLETED Phase 2 20 participants

A Trial of Aclaris Therapeutics, Inc. (ATI)-450 in Patients With Moderate-severe Novel Coronavirus Disease 2019 (COVID-19)

University of Kansas Medical Center

NCT04481685

COMPLETED Phase 1 19 participants

Electrical Stimulation for Critically Ill Covid-19 Patients

Baylor College of Medicine

NCT04685213

COMPLETED 18 participants

Performance of a Remote Monitoring Program for Patients Diagnosed With COVID-19

George Washington University

NCT05063812

COMPLETED Phase 1 15 participants

COVID-19 Study of Safety and Tolerability of Alvelestat

University of Alabama at Birmingham

NCT04539795

COMPLETED 12 participants

Cardiovascular, Pulmonary, and Integrative Functional Phenotypes in COVID-19 Survivors - Effect of Fenofibrate

University of Pennsylvania

NCT05080192

COMPLETED 12 participants

Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

Massachusetts General Hospital

NCT04476589

COMPLETED NA 6 participants

Implementation of COVID-19 Testing Strategies in Community Health Centers

Massachusetts General Hospital

NCT04802187

COMPLETED Phase 3 4 participants

Contrast Enhanced Ultrasound in COVID-19

Children's Hospital of Philadelphia

NCT04640038

COMPLETED Phase 1 3 participants

Exercise Therapy in Cancer Patients Who Are Recovering From COVID-19

Memorial Sloan Kettering Cancer Center

NCT04824443

Phase Distribution

PhaseTrial count
Early Phase 1 9
Phase 2 13
Phase 3 9
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Covid19 Trial Landscape

ClinicalTrials.gov lists 90 US studies indexed under Covid19, and 11 of those are currently open to recruitment — roughly 12% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Covid19 shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 22 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Covid19 is led by Massachusetts General Hospital with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 90 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Covid19?

PlainTrial tracks 90 US clinical trials for Covid19, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Covid19?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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