Browse All Conditions

Explore 28,964 medical conditions with active and completed U.S. clinical trial data drawn from ClinicalTrials.gov, the U.S. National Institutes of Health public registry. According to ClinicalTrials.gov, the National Institutes of Health public registry maintained by the U.S. National Library of Medicine catalogs more than 500,000 clinical studies across over 220 countries since 1997, with the U.S. Food and Drug Administration Amendments Act (FDAAA) of 2007 requiring registration for most studies of FDA-regulated products. See our methodology for refresh cadence.

PlainTrial's condition directory indexes every disease, disorder, syndrome, and medical condition with at least one clinical study registered on ClinicalTrials.gov. Each entry links to a per-condition profile page showing recruiting trials, completed studies, phase distribution, sponsor mix, and geographic coverage. We use the MeSH-aligned condition names submitted by trial sponsors to the National Library of Medicine, so a condition you find here is the same condition a clinician would search on PubMed or a researcher would tag in a grant application.

Use the alphabetical index to browse the full list, or sort by trial volume to find conditions with the deepest active research pipelines. Conditions with a "Recruiting" count in the third column have at least one trial currently enrolling participants - click through to see locations and eligibility. Conditions with high trial counts but zero recruiting slots usually reflect a maturing pipeline (Phase 3 studies are enrollment-closed) or a condition where standard-of-care has shifted research focus to combination therapies and post-approval surveillance.

The directory is comprehensive but not equally deep across conditions. Rare diseases may show fewer than a handful of trials because patient populations are limited - this is a feature of clinical research, not an indexing gap on our end. Common conditions (cancer subtypes, diabetes, hypertension, depression) show dozens to hundreds of studies because they attract the broadest sponsor investment. Every number on this page comes directly from ClinicalTrials.gov; we do not manually edit counts, and we update from the NLM bulk-export on a regular cadence so what you see reflects the most recent registry state we have ingested.

Breast Cancer1,251Healthy1,096Obesity1,057Prostate Cancer749Depression687Cancer621HIV Infections615Hypertension472Stroke456Non-Small Cell Lung Cancer450
A2,832B1,103C2,954D1,173E990F827G777H1,716I1,113J83K188L1,242M2,127N1,045O826P2,857Q24R1,694S3,019T976U530V511W241X47Y19Z17
Treemap Treemap of 10 categories, sized proportional to value. Breast Cancer - 1,251 Breast Cancer 1,251 Healthy - 1,096 Healthy 1,096 Obesity - 1,057 Obesity 1,057 Prostate Cancer - 749 Prostate Cancer 749 Depression - 687 Depression 687 Cancer - 621 Cancer 621 HIV Infections - 615 HIV Infections 615 Hypertension - 472 Hypertension 472 Stroke - 456 Stroke 456 Non-Small Cell Lung Cancer - 450 Non-Small Cell Lu… 450
Condition Trials
Locally Advanced Head and Neck Squamous Cell Carcinoma 6
Locally Advanced Hepatocellular Carcinoma 4
Locally Advanced HER2-Positive Breast Carcinoma 1
Locally Advanced HPV Positive Oropharynx Cancer 1
Locally Advanced Hypopharyngeal Squamous Cell Carcinoma 2
Locally Advanced Intrahepatic Cholangiocarcinoma 2
Locally Advanced Large-cell Neuroendocrine Carcinoma 1
Locally Advanced Laryngeal Squamous Cell Carcinoma 2
Locally Advanced Leiomyosarcoma 1
Locally Advanced Liposarcoma 1
Locally Advanced Lung Carcinoma 3
Locally Advanced Lung Neuroendocrine Neoplasm 2
Locally Advanced Lung Non-Small Cell Carcinoma 9
Locally Advanced Malignant Neoplasm 12
Locally Advanced Malignant Skin Neoplasm 1
Locally Advanced Malignant Solid Neoplasm 13
Locally Advanced Melanoma 6
Locally Advanced Merkel Cell Carcinoma 2
Locally Advanced Mucosal Melanoma 2
Locally Advanced Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma 1
Locally Advanced Nasal Cavity Squamous Cell Carcinoma 1
Locally Advanced Nasopharyngeal Squamous Cell Carcinoma 1
Locally Advanced Neuroendocrine Neoplasm 1
Locally Advanced Non Small Cell Lung Cancer 1
Locally Advanced NSCLC - Non-Small Cell Lung Cancer 1
Locally Advanced Olfactory Neuroblastoma 1
Locally Advanced or Early Breast Cancer 1
Locally Advanced or Metastatic and Unresectable HCC 1
Locally Advanced or Metastatic Breast Cancer 1
Locally Advanced or Metastatic Castration-resistant Prostate Cancer 1
Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen 1
Locally Advanced or Metastatic ER+ HER2- Breast Cancer 1
Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation 1
Locally Advanced or Metastatic Large Cell Neuroendocrine Carcinoma of the Lung 1
Locally Advanced or Metastatic Malignant Solid Tumors 2
Locally Advanced or Metastatic Melanoma 1
Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IV 2
Locally Advanced or Metastatic Non-Small Cell Lung Cancer 3
Locally Advanced or Metastatic Renal Cell Carcinoma 1
Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion 1
Locally Advanced or Metastatic Solid Tumors 6
Locally Advanced or Metastatic Solid Tumors Harboring a ROS1 or NTRK Alteration 1
Locally Advanced or Metastatic Solid Tumours 1
Locally Advanced or Metastatic Urothelial Carcinoma 1
Locally Advanced or Unresectable Metastatic Breast Cancer 1
Locally Advanced Oral Cavity Squamous Cell Carcinoma 1
Locally Advanced Oropharyngeal Squamous Cell Carcinoma 2
Locally Advanced Osteosarcoma 1
Locally Advanced Ovarian Carcinoma 1
Locally Advanced Pancreas Cancer 2