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NCT07674758 · ClinicalTrials.gov registry record
Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials
A clinical trial, sponsored by Vanderbilt University Medical Center.
- Recruiting
- Registry status
- 1,000
- Enrollment target
NCT07674758 is a clinical trial that is actively recruiting participants, run by Vanderbilt University Medical Center. The registered enrollment target is 1,000 participants.
The verdict
NCT07674758 is actively recruiting participants, sponsored by Vanderbilt University Medical Center.
- RECRUITING
- Registry status
- 1,000 participants
- Enrollment target
Study Summary
Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however, the evolution of heart dysfunction is not well-understood. The central objectives of this proposal are to elucidate this evolution of heart dysfunction and identify measures from cardiac MRI images that can predict death or significant heart disease in patients with DMD/BMD/MDC. This study will create a large clinical and cardiac MRI registry of dystrophin associated heart dysfunction, will utilize advanced image analysis techniques, including deep learning neural networks, to comprehensively evaluate every patient, and will create a risk toolkit accessible to clinicians around the world; this proposal has the potential to improve the quality of life in patients with dystrophin associated heart dysfunction by allowing for earlier and more intensive therapy in patients with severe disease and by identifying surrogate outcome measures for use in therapeutic trials.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2025-01-06 |
| Est. Completion | 2029-02-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07674758
The ClinicalTrials.gov registry entry for NCT07674758 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT07674758 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07674758 about?
NCT07674758 is a clinical study titled "Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials". Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however, the evolution of heart dysfunction is not well-understood. The central objectives of this proposal...
What is the current status of trial NCT07674758?
This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2025-01-06. Estimated completion is 2029-02-01.
Who is sponsoring clinical trial NCT07674758?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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