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NCT07672301 · ClinicalTrials.gov registry record · Phase 1
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
A Phase 1 study, sponsored by University of Chicago.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 150
- Enrollment target
NCT07672301: Recruiting Phase 1 study, sponsored by University of Chicago.
NCT07672301 is a Phase 1 study that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 150 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (150% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07672301, a Phase 1 study, is actively recruiting participants, sponsored by University of Chicago.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 150 participants
- Enrollment target
Study Summary
The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia or Total IntraVenous Anesthesia (TIVA). Primary Aim: assess same-day discharge rates between study arms (TIVA vs spinal). Secondary Aim: Postoperative comparison of recovery during PostOperative Anesthesia Care Unit (PACU) admission, diagnostic assessment scores; outcomes related to cognition, hemodynamic stability, pain, nausea and vomiting; analysis of IntraOperative electroencephalogram (EEG) monitoring metrics, e.g., total suppression time, average Bi-spectral Index monitor (BIS) value, Spectral Edge Frequency (SEF); ability for Physical Therapy (PT) evaluation prior to discharge; longterm-followup (LTFU), hospital readmission, return to surgery, etc.; adverse event (AE) monitoring.
Primary Outcome
Comparison of same-day discharge rates between patients receiving either total intravenous anesthesia (TIVA) or spinal-block anesthesia, during total knee arthroplasty (TKA).
Interventions
- DEVICE Electroencephalogram (EEG)
- COMBINATION_PRODUCT Total IntraVenous Anesthesia (TIVA)
- COMBINATION_PRODUCT Spinal-Block
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2026-03-11 |
| Est. Completion | 2028-06 |
| Phase | Phase 1 |
What NCT07672301 shows while recruiting
NCT07672301 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (150% higher).
The record links to 0 conditions, and to 3 interventions - of which Electroencephalogram (EEG) is the first listed.
NCT07672301 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07672301 about?
NCT07672301 is a clinical study titled "Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty". The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia or Total IntraVenous Anesthesia (TIVA). Primary Aim: assess same-day ...
What is the current status of trial NCT07672301?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 150 participants. The study started on 2026-03-11. Estimated completion is 2028-06.
What interventions are being tested in trial NCT07672301?
The interventions under investigation include: Electroencephalogram (EEG) (DEVICE), Total IntraVenous Anesthesia (TIVA) (COMBINATION_PRODUCT), Spinal-Block (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT07672301?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07672301's enrollment target sits among peer trials
150 363rd of 2000 higher than 1,620 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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