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NCT07649291 · ClinicalTrials.gov registry record · Phase 2
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
A Phase 2 study, sponsored by VA Office of Research and Development.
- Not yet
- Registry status
- Phase 2
- Development phase
- 102
- Enrollment target
NCT07649291: Clinical Trial Phase 2 study, sponsored by VA Office of Research and Development.
NCT07649291 is a Phase 2 study that has not yet begun recruiting, run by VA Office of Research and Development. The registered enrollment target is 102 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07649291, a Phase 2 study, has not yet begun recruiting, sponsored by VA Office of Research and Development.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 102 participants
- Enrollment target
Study Summary
Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans. Many Veterans with KOA also experience depressive symptoms, which can worsen pain, reduce motivation to exercise, and make recovery more difficult. This study will test whether a structured hybrid aerobic exercise program that combines supervised and home-based walking with the medication duloxetine can improve physical function, reduce pain, lessen depressive symptoms, and improve overall health-related outcomes in Veterans with KOA. The goal of this research is to develop a practical and scalable treatment strategy that could improve rehabilitation and quality of life for Veterans with chronic knee pain and depressive symptoms and potentially be adapted for other chronic musculoskeletal conditions treated within the VA healthcare system.
Interventions
- DRUG Placebo
- DRUG Duloxetine
- BEHAVIORAL Exercise
- BEHAVIORAL PT referral
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2027-03-01 |
| Est. Completion | 2032-09-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07649291
The ClinicalTrials.gov registry entry for NCT07649291 describes a study currently listed as not yet recruiting, categorized as Phase 2. The registered enrollment target is 102 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,668 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Placebo is the first listed.
NCT07649291 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07649291 about?
NCT07649291 is a clinical study titled "Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)". Knee osteoarthritis (KOA) is one of the most common causes of chronic pain, mobility problems, and disability among United States Veterans. Many Veterans with KOA also experience depressive symptoms, which can worsen pain, reduce motivation to exercise, and make recovery more difficult. This study w...
What is the current status of trial NCT07649291?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 102 participants. The study started on 2027-03-01. Estimated completion is 2032-09-01.
What interventions are being tested in trial NCT07649291?
The interventions under investigation include: Placebo (DRUG), Duloxetine (DRUG), Exercise (BEHAVIORAL), PT referral (BEHAVIORAL).
Who is sponsoring clinical trial NCT07649291?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
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