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NCT07646587 · ClinicalTrials.gov registry record · Phase 2
A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)
A Phase 2 study, sponsored by Windward Bio.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 105
- Enrollment target
NCT07646587: Recruiting Phase 2 study, sponsored by Windward Bio.
NCT07646587 is a Phase 2 study that is actively recruiting participants, run by Windward Bio. The registered enrollment target is 105 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (21% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07646587, a Phase 2 study, is actively recruiting participants, sponsored by Windward Bio.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 105 participants
- Enrollment target
Study Summary
This study is trying to identify the right dose of a long-acting medicine called WIN378 for people with moderate - severe chronic obstructive pulmonary disease (COPD). WIN378 blocks the action of a protein called TSLP that causes inflammation in the lung and may contribute to COPD control and symptoms. The study will test how doses of WIN378 are handled by the body (pharmacokinetics) and assess the safety of the medicine and markers of COPD inflammation in exhaled breath and blood, lung function and COPD control (pharmacodynamics)
Interventions
- DRUG Placebo
- DRUG WIN378
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2026-06-02 |
| Est. Completion | 2028-01-07 |
| Phase | Phase 2 |
What NCT07646587 shows while recruiting
NCT07646587 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (21% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07646587 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07646587 about?
NCT07646587 is a clinical study titled "A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)". This study is trying to identify the right dose of a long-acting medicine called WIN378 for people with moderate - severe chronic obstructive pulmonary disease (COPD). WIN378 blocks the action of a protein called TSLP that causes inflammation in the lung and may contribute to COPD control and sympto...
What is the current status of trial NCT07646587?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 105 participants. The study started on 2026-06-02. Estimated completion is 2028-01-07.
What interventions are being tested in trial NCT07646587?
The interventions under investigation include: Placebo (DRUG), WIN378 (DRUG).
Who is sponsoring clinical trial NCT07646587?
This trial is sponsored by Windward Bio, which has 2 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07646587's enrollment target sits among peer trials
105 650th of 2000 higher than 1,341 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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