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NCT07603375 · ClinicalTrials.gov registry record · Phase 2
Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
A Phase 2 study, sponsored by Duke University.
- Not yet
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT07603375: Clinical Trial Phase 2 study, sponsored by Duke University.
NCT07603375 is a Phase 2 study that has not yet begun recruiting, run by Duke University. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07603375, a Phase 2 study, has not yet begun recruiting, sponsored by Duke University.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
The goal of this trial is to learn if adding consolidative chemotherapy to routine chemoradiation can better control both local recurrence and metastasis and reduce the need for surgical intervention.
Primary Outcome
cCR defined as absence of malignancy on endoscopic biopsies obtained at the time of reassessment following neoadjuvant therapy
Interventions
- DRUG FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-08-01 |
| Est. Completion | 2034-02 |
| Phase | Phase 2 |
What is known before NCT07603375 opens enrollment
NCT07603375 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 1 intervention - of which FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) is the first listed.
NCT07603375 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07603375 about?
NCT07603375 is a clinical study titled "Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma". The goal of this trial is to learn if adding consolidative chemotherapy to routine chemoradiation can better control both local recurrence and metastasis and reduce the need for surgical intervention.
What is the current status of trial NCT07603375?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2026-08-01. Estimated completion is 2034-02.
What interventions are being tested in trial NCT07603375?
The interventions under investigation include: FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) (DRUG).
Who is sponsoring clinical trial NCT07603375?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07603375's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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