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NCT07577843 · ClinicalTrials.gov registry record · Phase 3
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease
A Phase 3 study, sponsored by Janssen Research & Development.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 460
- Enrollment target
NCT07577843: Recruiting Phase 3 study, sponsored by Janssen Research & Development.
NCT07577843 is a Phase 3 study that is actively recruiting participants, run by Janssen Research & Development. The registered enrollment target is 460 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07577843, a Phase 3 study, is actively recruiting participants, sponsored by Janssen Research & Development.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 460 participants
- Enrollment target
Study Summary
The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at Week 48 in participants with moderately to severely active Crohn's disease (a long-term, progressive \[worsens with time\] and life-threatening disease of the intestine).
Primary Outcome
Clinical remission is defined as a Crohn's Disease Activity Index (CDAI) score less than (\<) 150. CDAI scores range from 0 to approximately 600. Higher score indicates higher disease activity.
Interventions
- DRUG Guselkumab
- DRUG JNJ-78934804
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 460 participants |
| Start Date | 2026-05-22 |
| Est. Completion | 2030-07-12 |
| Phase | Phase 3 |
What NCT07577843 shows while recruiting
NCT07577843 is an interventional study that assigns participants to a tested intervention. The registered 460 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 2 interventions - of which Guselkumab is the first listed.
NCT07577843 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07577843 about?
NCT07577843 is a clinical study titled "A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease". The purpose of this study is to assess how well JNJ-78934804 works (efficacy) and how safe it is (safety) as compared to guselkumab at Week 48 in participants with moderately to severely active Crohn's disease (a long-term, progressive \[worsens with time\] and life-threatening disease of the intest...
What is the current status of trial NCT07577843?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 460 participants. The study started on 2026-05-22. Estimated completion is 2030-07-12.
What interventions are being tested in trial NCT07577843?
The interventions under investigation include: Guselkumab (DRUG), JNJ-78934804 (DRUG).
Who is sponsoring clinical trial NCT07577843?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07577843's enrollment target sits among peer trials
460 823rd of 2000 higher than 1,174 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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