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NCT07559604 · ClinicalTrials.gov registry record · NA
The Effects of Mango on Gut Health Markers
A NA study, sponsored by Loma Linda University.
- Not yet
- Registry status
- NA
- Development phase
- 31
- Enrollment target
NCT07559604 is a NA study that has not yet begun recruiting, run by Loma Linda University. The registered enrollment target is 31 participants.
The verdict
NCT07559604, a NA study, has not yet begun recruiting, sponsored by Loma Linda University.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 31 participants
- Enrollment target
Study Summary
This is an ancillary study of NCT06159543, which was a clinical trial that examined the effect of a 12-week 1.5 cups daily mango crossover intervention on cardiometabolic outcomes in individuals with prediabetes, male and female, and 40-60 years of age. The goal of this ancillary study is to test the effect of the mango intervention on gut health markers in individuals with prediabetes. The main questions it aims to answer are: 1. What is the effect of 1.5 cups per day of fresh mango over 12 weeks on indicators of gut permeability as measured by lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14)? 2. What is the effect of 1.5 cups per day of fresh mango over 12 weeks on microbiome modulation as estimated by short chain fatty acids (SCFAs)? Secondarily: 1. Is LBP a mediator of the relationship between systemic inflammation \[as determined by C-reactive protein, E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)\] and SCFAs? 2. Is LBP a mediator of the relationship between insulin resistance \[as determined by HOMA-IR\] and SCFAs? 3. Is sCD14 a mediator of the relationship between systemic inflammation \[as determined by C-reactive protein, E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1)\] and SCFAs? 4. Is sCD14 a mediator of the relationship between insulin resistance \[as determined by HOMA-IR\] and SCFAs? Researchers will compare the 12 weeks participants consume mango to the 12 weeks the participants are not consuming mango to see if there are differences in LBP, sCD14, and SCFAs. As noted, this is an ancillary study of NCT06159543. Fasting blood was collected at baseline, and at the end of each phase of NCT06159543. This blood will be used to analyze LBP, sCD14 and SCFAs. Fasting blood and insulin were analyzed in NCT06159543, and will used to calculate HOMA-IR in the ancillary study. C-reactive protein, E-selectin, intercellular adhesion
Interventions
- BEHAVIORAL Mango
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2026-09 |
| Est. Completion | 2027-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07559604
The ClinicalTrials.gov registry entry for NCT07559604 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 31 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Loma Linda University, which has 237 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Mango is the first listed.
NCT07559604 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07559604 about?
NCT07559604 is a clinical study titled "The Effects of Mango on Gut Health Markers". This is an ancillary study of NCT06159543, which was a clinical trial that examined the effect of a 12-week 1.5 cups daily mango crossover intervention on cardiometabolic outcomes in individuals with prediabetes, male and female, and 40-60 years of age. The goal of this ancillary study is to test th...
What is the current status of trial NCT07559604?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 31 participants. The study started on 2026-09. Estimated completion is 2027-12.
What interventions are being tested in trial NCT07559604?
The interventions under investigation include: Mango (BEHAVIORAL).
Who is sponsoring clinical trial NCT07559604?
This trial is sponsored by Loma Linda University, which has 237 total clinical trials registered on ClinicalTrials.gov.
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