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NCT07549490 · ClinicalTrials.gov registry record · NA
Human Experimental Models of Pain (HEMP)
A NA study, sponsored by National Center for Complementary and Integrative Health (NCCIH).
- Not yet
- Registry status
- NA
- Development phase
- 25
- Enrollment target
NCT07549490 is a NA study that has not yet begun recruiting, run by National Center for Complementary and Integrative Health (NCCIH). The registered enrollment target is 25 participants.
The verdict
NCT07549490, a NA study, has not yet begun recruiting, sponsored by National Center for Complementary and Integrative Health (NCCIH).
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
Study Summary
This pilot study will test an innovative way to establish how pain medicines provide analgesia in healthy adults. The study uses a group of short, controlled pain tests to look at different types of pain responses in the body. The main goal is to find out if this testing approach can show the pain-relieving effects of 2 medicines, pregabalin and naproxen versus placebo, and show how they provide relief of different types of pain. The study hypothesis is that this pain testing approach administered as a battery would be able to tell the difference between a medicine that works mainly in the brain and spinal cord (pregabalin) and a medicine that works mainly on inflammation in body tissues (naproxen). Up to 25 healthy adults will take part. Each participant will receive all 3 study treatments, pregabalin, naproxen, and placebo, administered in random order during separate study periods. The order will be assigned by chance. Neither the participant nor the study team will know which treatment is given at each visit. The study includes several experimental pain tests. These include: a heat and capsaicin skin test that causes short-term skin sensitivity, a UVB light test that causes a temporary sunburn-like sensitivity, and a cold pressor test, in which a hand is placed in very cold water for a short time. Participants will also have sensory testing to measure how they feel touch, pressure, pinprick, warmth, heat, and cold. Blood samples will be collected to measure study drug levels. Urine samples, vital signs, and other safety checks will also be done. Each treatment visit includes testing before and for several hours after taking the study drug. There will be a washout period of at least 48 hours between treatments. Total participation may last up to about 10 weeks. This study is not expected to provide direct medical benefit to participants. The information learned may help researchers improve early testing of future pain treatments....
Interventions
- DRUG Placebo
- DRUG Naproxen
- DRUG Pregabalin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2026-07-15 |
| Est. Completion | 2030-12-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07549490
The ClinicalTrials.gov registry entry for NCT07549490 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 25 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Center for Complementary and Integrative Health (NCCIH), which has 203 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT07549490 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07549490 about?
NCT07549490 is a clinical study titled "Human Experimental Models of Pain (HEMP)". This pilot study will test an innovative way to establish how pain medicines provide analgesia in healthy adults. The study uses a group of short, controlled pain tests to look at different types of pain responses in the body. The main goal is to find out if this testing approach can show the pain-r...
What is the current status of trial NCT07549490?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 25 participants. The study started on 2026-07-15. Estimated completion is 2030-12-31.
What interventions are being tested in trial NCT07549490?
The interventions under investigation include: Placebo (DRUG), Naproxen (DRUG), Pregabalin (DRUG).
Who is sponsoring clinical trial NCT07549490?
This trial is sponsored by National Center for Complementary and Integrative Health (NCCIH), which has 203 total clinical trials registered on ClinicalTrials.gov.
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