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NCT07528352 · ClinicalTrials.gov registry record · Phase 1
External Beam Radiotherapy Followed by Bispecific Antibody Therapy for Relapsed/Refractory DLBCL
A Phase 1 study, sponsored by University of Utah.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
NCT07528352: Recruiting Phase 1 study, sponsored by University of Utah.
NCT07528352 is a Phase 1 study that is actively recruiting participants, run by University of Utah. The registered enrollment target is 12 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07528352, a Phase 1 study, is actively recruiting participants, sponsored by University of Utah.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
The purpose of this clinical trial is to assess the safety and tolerability of ration therapy followed by receiving epcoritamab or glofitamab in patients with relapsed/refractory diffuse large B-cell lymphoma.
Primary Outcome
To assess the safety and tolerability of radiation therapy followed by bispecific antibody (BsAb) therapy (Epcoritamab or Glofitamab) in patients with R/R DLBCL. The study proposes this combination is safe and feasible if ≤20% of patients experience grade 3 or 4 cytokine release syndrome (CRS) (≤2 of 10 patients) and (2) ≤10% of patients experience grade 3 or 4 immune effector cell-associated neurotoxicity (ICANS) (≤1 of 10 patients).
Interventions
- DRUG Glofitamab
- DRUG Epcoritamab
- RADIATION External Beam Radiation Therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2026-06-01 |
| Est. Completion | 2031-06 |
| Phase | Phase 1 |
What NCT07528352 shows while recruiting
NCT07528352 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower).
The record links to 0 conditions, and to 3 interventions - of which Glofitamab is the first listed.
NCT07528352 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07528352 about?
NCT07528352 is a clinical study titled "External Beam Radiotherapy Followed by Bispecific Antibody Therapy for Relapsed/Refractory DLBCL". The purpose of this clinical trial is to assess the safety and tolerability of ration therapy followed by receiving epcoritamab or glofitamab in patients with relapsed/refractory diffuse large B-cell lymphoma.
What is the current status of trial NCT07528352?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2026-06-01. Estimated completion is 2031-06.
What interventions are being tested in trial NCT07528352?
The interventions under investigation include: Glofitamab (DRUG), Epcoritamab (DRUG), External Beam Radiation Therapy (RADIATION).
Who is sponsoring clinical trial NCT07528352?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07528352's enrollment target sits among peer trials
12 1852nd of 2000 higher than 90 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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