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NCT07512284 · ClinicalTrials.gov registry record · Phase 2
Mindfulness Engaged Neurostimulation for Depression (MEND II)
A Phase 2 study, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 120
- Enrollment target
NCT07512284 is a Phase 2 study that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 120 participants.
The verdict
NCT07512284, a Phase 2 study, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 120 participants
- Enrollment target
Study Summary
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent theta burst stimulation (iTBS) - a type of rTMS with digital mindfulness training to engage brain plasticity, enhance cognition and alleviate depression symptoms in individuals with TRD.
Interventions
- COMBINATION_PRODUCT Medi-TBS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2026-05-01 |
| Est. Completion | 2029-04-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07512284
The ClinicalTrials.gov registry entry for NCT07512284 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Medi-TBS is the first listed.
NCT07512284 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07512284 about?
NCT07512284 is a clinical study titled "Mindfulness Engaged Neurostimulation for Depression (MEND II)". Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of \~30%. Additionally, r...
What is the current status of trial NCT07512284?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 120 participants. The study started on 2026-05-01. Estimated completion is 2029-04-30.
What interventions are being tested in trial NCT07512284?
The interventions under investigation include: Medi-TBS (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT07512284?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
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