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NCT07512154 · ClinicalTrials.gov registry record · NA
Precision Radiotherapy Enabled by Molecular MRI
A NA study, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT07512154: Recruiting NA study, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
NCT07512154 is a NA study that is actively recruiting participants, run by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07512154, a NA study, is actively recruiting participants, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
This is a research study to determine if a novel molecular magnetic resonance imaging (MRI) technique, called amide proton transfer (APT) imaging, is useful in identifying the most aggressive areas of tumor needed for radiotherapy of brain tumors.
Primary Outcome
A reduction in APTw signal following treatment suggests a positive response to therapy (active tumor APTw = 3-4% vs. necrosis/no tumor APTw 1-2%). A 1% greater reduction in mean APTw signal change within the Gd-enhancing tumor region from baseline (pre-RT) to post-RT in the APT-RT arm, compared to the control arm.
Interventions
- RADIATION Standard radiotherapy
- RADIATION Amide proton transfer radiotherapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-04-29 |
| Est. Completion | 2032-05 |
| Phase | NA |
What NCT07512154 shows while recruiting
NCT07512154 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Standard radiotherapy is the first listed.
NCT07512154 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07512154 about?
NCT07512154 is a clinical study titled "Precision Radiotherapy Enabled by Molecular MRI". This is a research study to determine if a novel molecular magnetic resonance imaging (MRI) technique, called amide proton transfer (APT) imaging, is useful in identifying the most aggressive areas of tumor needed for radiotherapy of brain tumors.
What is the current status of trial NCT07512154?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2026-04-29. Estimated completion is 2032-05.
What interventions are being tested in trial NCT07512154?
The interventions under investigation include: Standard radiotherapy (RADIATION), Amide proton transfer radiotherapy (RADIATION).
Who is sponsoring clinical trial NCT07512154?
This trial is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, which has 523 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07512154's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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