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NCT07485803 · ClinicalTrials.gov registry record · Phase 4
Methadone in the Management of Post-Operative Pain in Total Knee Replacement
A Phase 4 study, sponsored by AdventHealth.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 192
- Enrollment target
NCT07485803: Recruiting Phase 4 study, sponsored by AdventHealth.
NCT07485803 is a Phase 4 study that is actively recruiting participants, run by AdventHealth. The registered enrollment target is 192 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (63% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07485803, a Phase 4 study, is actively recruiting participants, sponsored by AdventHealth.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 192 participants
- Enrollment target
Study Summary
The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.
Primary Outcome
Opioid use will be calculated using morphine milligram equivalents (MME). Patients will keep a log to track opioid consumption.
Interventions
- DRUG Methadone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 192 participants |
| Start Date | 2026-06-01 |
| Est. Completion | 2028-06 |
| Phase | Phase 4 |
What NCT07485803 shows while recruiting
NCT07485803 is an interventional study that assigns participants to a tested intervention. The registered 192 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (63% lower).
The record links to 0 conditions, and to 1 intervention - of which Methadone is the first listed.
NCT07485803 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07485803 about?
NCT07485803 is a clinical study titled "Methadone in the Management of Post-Operative Pain in Total Knee Replacement". The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.
What is the current status of trial NCT07485803?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 192 participants. The study started on 2026-06-01. Estimated completion is 2028-06.
What interventions are being tested in trial NCT07485803?
The interventions under investigation include: Methadone (DRUG).
Who is sponsoring clinical trial NCT07485803?
This trial is sponsored by AdventHealth, which has 95 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07485803's enrollment target sits among peer trials
192 451st of 2000 higher than 1,548 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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