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NCT07449923 · ClinicalTrials.gov registry record · Phase 3
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
A Phase 3 study of Diabetic Macular Edema and Diabetic Macular Edema (DME), sponsored by EyePoint Pharmaceuticals.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 240
- Enrollment target
- 12
- Study locations
NCT07449923: Recruiting Phase 3 study of Diabetic Macular Edema and Diabetic Macular Edema (DME), sponsored by EyePoint Pharmaceuticals.
NCT07449923 is a Phase 3 study of Diabetic Macular Edema and Diabetic Macular Edema (DME) that is actively recruiting participants, run by EyePoint Pharmaceuticals. The registered enrollment target is 240 participants, below the 3,791-participant average among 63 other Diabetic Macular Edema trials with a reported enrollment target (94% lower). The trial reports 12 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07449923, a Phase 3 study of Diabetic Macular Edema and Diabetic Macular Edema (DME), is actively recruiting participants, sponsored by EyePoint Pharmaceuticals.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 240 participants
- Enrollment target
- 12
- Study locations
Study Summary
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Primary Outcome
BCVA Early Treatment Diabetic Retinopathy Study (ETDRS) letter score change from Baseline to the average of Weeks 52 and 56
Conditions Studied
Interventions
- DRUG EYP-1901
- DRUG Aflibercept (2.0 mg)
Study Locations (12)
Florida
- Retina Specialty Institute - Pensacola
- Retina Vitreous Associates of Florida - Saint Petersburg - St. Petersburg
Arizona
- Phoenix Retina Clinical Trials, LLC - North Phoenix - Phoenix
California
- Retinal Consultants Medical Group - Modesto - Modesto
Colorado
- Retina Specialists of Colorado - Arvada - Arvada
Connecticut
- Coastal Eye Surgeons, LLC - Greenwich
Indiana
- Associated Vitreoretinal & Uveitis Consultants - Carmel - Carmel
Maryland
- Mid Atlantic Retina Specialists - Hagerstown - Hagerstown
North Carolina
- Graystone Eye - Hickory Office - Hickory
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2026-02-09 |
| Est. Completion | 2028-08 |
| Phase | Phase 3 |
What NCT07449923 shows while recruiting
NCT07449923 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 3,791-participant average among 63 other Diabetic Macular Edema trials with a reported enrollment target (94% lower).
The record links to 3 conditions, with Diabetic Macular Edema appearing as the primary indexed condition, and to 2 interventions - of which EYP-1901 is the first listed.
NCT07449923 lists 12 locations in 11 states (Florida, Arizona, California).
Frequently Asked Questions
What is clinical trial NCT07449923 about?
NCT07449923 is a clinical study titled "CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME". This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
What is the current status of trial NCT07449923?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 240 participants. The study started on 2026-02-09. Estimated completion is 2028-08.
What conditions does trial NCT07449923 study?
This clinical trial studies the following conditions: Diabetic Macular Edema, Diabetic Macular Edema (DME), DME.
What interventions are being tested in trial NCT07449923?
The interventions under investigation include: EYP-1901 (DRUG), Aflibercept (2.0 mg) (DRUG).
Who is sponsoring clinical trial NCT07449923?
This trial is sponsored by EyePoint Pharmaceuticals, which has 16 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07449923 being conducted?
This trial has 12 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetic Macular Edema
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Where NCT07449923's enrollment target sits among peer trials
240 19th of 63 higher than 44 of 63 other Diabetic Macular Edema trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetic Macular Edema trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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