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NCT07424352 · ClinicalTrials.gov registry record · NA

Knee Osteoarthritis Rehabilitation Through Rotational Inertia

A NA study of Knee Arthritis, Osteoarthritis, sponsored by University of Colorado, Denver.

Recruiting
Registry status
NA
Development phase
60
Enrollment target
1
Study location

NCT07424352: Recruiting NA study of Knee Arthritis, Osteoarthritis, sponsored by University of Colorado, Denver.

NCT07424352 is a NA study of Knee Arthritis, Osteoarthritis that is actively recruiting participants, run by University of Colorado, Denver. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT07424352, a NA study of Knee Arthritis, Osteoarthritis, is actively recruiting participants, sponsored by University of Colorado, Denver.

RECRUITING
Registry status
NA
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods. The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail. The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.

Primary Outcome

Stair-stepping smoothness quantifies motor coordination during the step-up-and-over test by analyzing the fluidity and consistency of limb movements while ascending and descending stairs. It is calculated using a jerk-based smoothness metric adapted from Gonzales et al., where jerk is defined as the third derivative of the position trajectory with respect to time. The smoothness index is derived by numerically differentiating the position data x(t) obtained from motion capture three times to cal

Interventions

  • OTHER Eccentric resistance training

Study Locations (1)

Colorado

  • University of Colorado, Denver - Aurora

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-08-20
Est. Completion 2029-05-31
Phase NA
University of Colorado, Denver

1,283 total trials

What NCT07424352 shows while recruiting

NCT07424352 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).

The record links to 1 condition, with Knee Arthritis, Osteoarthritis appearing as the primary indexed condition, and to 1 intervention - of which Eccentric resistance training is the first listed.

NCT07424352 reports a single indexed study location in Colorado.

Frequently Asked Questions

What is clinical trial NCT07424352 about?

NCT07424352 is a clinical study titled "Knee Osteoarthritis Rehabilitation Through Rotational Inertia". This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the...

What is the current status of trial NCT07424352?

This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2025-08-20. Estimated completion is 2029-05-31.

What conditions does trial NCT07424352 study?

This clinical trial studies the following conditions: Knee Arthritis, Osteoarthritis.

What interventions are being tested in trial NCT07424352?

The interventions under investigation include: Eccentric resistance training (OTHER).

Who is sponsoring clinical trial NCT07424352?

This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07424352 being conducted?

This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

How this trial's enrollment target compares

Where NCT07424352's enrollment target sits among peer trials

60 1164th of 2000 higher than 745 of 2,000 other NA trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT07424352, the US trial registry maintained by the National Library of Medicine. NCT07424352 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.