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NCT07420530 · ClinicalTrials.gov registry record · Early Phase 1
Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion
A Early Phase 1 study of Vocal Cord Dysfunction and Exercise-Induced Vocal Cord Dysfunction, sponsored by Indiana University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT07420530 is a Early Phase 1 study of Vocal Cord Dysfunction and Exercise-Induced Vocal Cord Dysfunction that is actively recruiting participants, run by Indiana University. The registered enrollment target is 120 participants, above the 28-participant average among 3 other Vocal Cord Dysfunction trials with a reported enrollment target (329% higher). The trial reports 1 study location across 1 state.
The verdict
NCT07420530, a Early Phase 1 study of Vocal Cord Dysfunction and Exercise-Induced Vocal Cord Dysfunction, is actively recruiting participants, sponsored by Indiana University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO. For the study there are three separate visits: 1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.
Conditions Studied
Interventions
- DRUG Carbon Dioxide
- BEHAVIORAL Breathing treatment
Study Locations (1)
Indiana
- Indiana University - Bloomington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2026-04-20 |
| Est. Completion | 2032-01-20 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07420530
The ClinicalTrials.gov registry entry for NCT07420530 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 28-participant average among 3 other Vocal Cord Dysfunction trials with a reported enrollment target (329% higher). The listed sponsor is Indiana University, which has 890 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Vocal Cord Dysfunction appearing as the primary indexed condition, and to 2 interventions - of which Carbon Dioxide is the first listed.
NCT07420530 reports 1 study location spanning 1 distinct geographic area - top geographies include Indiana.
Frequently Asked Questions
What is clinical trial NCT07420530 about?
NCT07420530 is a clinical study titled "Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion". The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniatur...
What is the current status of trial NCT07420530?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 120 participants. The study started on 2026-04-20. Estimated completion is 2032-01-20.
What conditions does trial NCT07420530 study?
This clinical trial studies the following conditions: Vocal Cord Dysfunction, Exercise-Induced Vocal Cord Dysfunction, Paradoxical Vocal Fold Motion.
What interventions are being tested in trial NCT07420530?
The interventions under investigation include: Carbon Dioxide (DRUG), Breathing treatment (BEHAVIORAL).
Who is sponsoring clinical trial NCT07420530?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07420530 being conducted?
This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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