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NCT07392372 · ClinicalTrials.gov registry record · Phase 1

A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV

A Phase 1 study of HIV-1-infection, sponsored by BioNTech SE.

Recruiting
Registry status
Phase 1
Development phase
61
Enrollment target
3
Study locations

NCT07392372 is a Phase 1 study of HIV-1-infection that is actively recruiting participants, run by BioNTech SE. The registered enrollment target is 61 participants, below the 351-participant average among 71 other HIV-1-infection trials with a reported enrollment target (83% lower). The trial reports 3 study locations across 2 states.

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The verdict

NCT07392372, a Phase 1 study of HIV-1-infection, is actively recruiting participants, sponsored by BioNTech SE.

RECRUITING
Registry status
Phase 1
Development phase
61 participants
Enrollment target
3
Study locations

Study Summary

This study will test the safety and blood levels of the antibody BNT351 in people living without and with human immunodeficiency virus (HIV). This study will also test the anti-viral activity of BNT351 in people living with HIV (PLWH) with detectable virus levels. The main goals of this study are: * To learn about the safety of BNT351 and check for side effects. * To measure the amount of BNT351 antibody in blood over time. * To test the amount of HIV in the blood at different times after treatment with BNT351 in people living with HIV.

Conditions Studied

HIV-1-infection

Interventions

  • DRUG Placebo
  • DRUG BNT351

Study Locations (3)

Other

  • UK Köln - Cologne
  • CRS Mannheim - Mannheim

Maryland

  • Johns Hopkins - Baltimore

Trial Details

FieldValue
Enrollment Target 61 participants
Start Date 2026-02-09
Est. Completion 2027-06
Phase Phase 1

Sponsor

BioNTech SE

53 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07392372

The ClinicalTrials.gov registry entry for NCT07392372 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 61 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 351-participant average among 71 other HIV-1-infection trials with a reported enrollment target (83% lower). The listed sponsor is BioNTech SE, which has 53 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with HIV-1-infection appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT07392372 reports 3 study locations spanning 2 distinct geographic areas - top geographies include Other, Maryland.

Frequently Asked Questions

What is clinical trial NCT07392372 about?

NCT07392372 is a clinical study titled "A Clinical Trial Investigating the Safety and Biological Activity of the Antibody BNT351 in Adults Living Without and With HIV". This study will test the safety and blood levels of the antibody BNT351 in people living without and with human immunodeficiency virus (HIV). This study will also test the anti-viral activity of BNT351 in people living with HIV (PLWH) with detectable virus levels. The main goals of this study are: ...

What is the current status of trial NCT07392372?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 61 participants. The study started on 2026-02-09. Estimated completion is 2027-06.

What conditions does trial NCT07392372 study?

This clinical trial studies the following conditions: HIV-1-infection.

What interventions are being tested in trial NCT07392372?

The interventions under investigation include: Placebo (DRUG), BNT351 (DRUG).

Who is sponsoring clinical trial NCT07392372?

This trial is sponsored by BioNTech SE, which has 53 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07392372 being conducted?

This trial has 3 study locations across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.