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NCT07390760 · ClinicalTrials.gov registry record · NA
Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy
A NA study of Children With Cerebral Palsy, sponsored by East Carolina University.
- Recruiting
- Registry status
- NA
- Development phase
- 16
- Enrollment target
- 1
- Study location
NCT07390760: Recruiting NA study of Children With Cerebral Palsy, sponsored by East Carolina University.
NCT07390760 is a NA study of Children With Cerebral Palsy that is actively recruiting participants, run by East Carolina University. The registered enrollment target is 16 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07390760, a NA study of Children With Cerebral Palsy, is actively recruiting participants, sponsored by East Carolina University.
- RECRUITING
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
- 1
- Study location
Study Summary
Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological conditions. Although RIC is thought to influence neuroplasticity through neural, metabolic, and humoral pathways, its effects on spinal-level mechanisms remain poorly understood. Emerging evidence indicates that neuroplastic adaptations occur not only at the cortical level but also within the spinal cord. Moreover, altered spinal reflex excitability is associated with spasticity, balance impairments, and functional limitations in children with cerebral palsy (CP), yet the role of spinal reflex modulations in response to RIC and balance training remains under expplored in this population. Therefore, this study aims to investigate the effects of RIC combined with balance training on spinal reflex modulation in children with CP.
Primary Outcome
The maximal (peak) H-reflex amplitude will be determined from the recruitment (stimulus-response) curve. The Hmax amplitude provides an estimate of the number or proportion of motor neurons (MNs) activated from the total MN pool, reflecting spinal reflex modulations and spinal neuroplasticity.
Conditions Studied
Interventions
- BEHAVIORAL Remote Ischemic Condtioning (RIC)
- BEHAVIORAL Sham conditioning
- BEHAVIORAL Balance training
Study Locations (1)
North Carolina
- East Carolina University - Greenville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2025-07-28 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT07390760 shows while recruiting
NCT07390760 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Children With Cerebral Palsy appearing as the primary indexed condition, and to 3 interventions - of which Remote Ischemic Condtioning (RIC) is the first listed.
NCT07390760 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07390760 about?
NCT07390760 is a clinical study titled "Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy". Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological cond...
What is the current status of trial NCT07390760?
This trial is currently recruiting. It is a NA study. The enrollment target is 16 participants. The study started on 2025-07-28. Estimated completion is 2026-12-31.
What conditions does trial NCT07390760 study?
This clinical trial studies the following conditions: Children With Cerebral Palsy.
What interventions are being tested in trial NCT07390760?
The interventions under investigation include: Remote Ischemic Condtioning (RIC) (BEHAVIORAL), Sham conditioning (BEHAVIORAL), Balance training (BEHAVIORAL).
Who is sponsoring clinical trial NCT07390760?
This trial is sponsored by East Carolina University, which has 58 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07390760 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07390760's enrollment target sits among peer trials
16 1871st of 2000 higher than 120 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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