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NCT07357298 · ClinicalTrials.gov registry record · Phase 3
Phase III Trial of Brain MRI Surveillance in Stage IV Breast Cancer
A Phase 3 study, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 156
- Enrollment target
NCT07357298 is a Phase 3 study that is actively recruiting participants, run by H. Lee Moffitt Cancer Center and Research Institute. The registered enrollment target is 156 participants.
The verdict
NCT07357298, a Phase 3 study, is actively recruiting participants, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 156 participants
- Enrollment target
Study Summary
This randomized, multi-institutional phase III trial evaluates whether routine surveillance brain MRI every 6 months improves detection and treatment characteristics of brain metastases in neurologically asymptomatic patients with stage IV breast cancer. Patients are stratified by receptor subtype, age, prior therapy, and study site, then randomized 1:1 to either scheduled surveillance MRIs or standard-of-care symptom-triggered imaging. The study aims to determine whether earlier detection leads to differences in treatment modality, frequency of brain metastases, leptomeningeal disease incidence, quality of life, and survival outcomes.
Interventions
- DIAGNOSTIC_TEST Surveillance Brain MRI
- DIAGNOSTIC_TEST Standard of Care Brain Imaging
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 156 participants |
| Start Date | 2026-02-25 |
| Est. Completion | 2030-02 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07357298
The ClinicalTrials.gov registry entry for NCT07357298 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 156 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is H. Lee Moffitt Cancer Center and Research Institute, which has 502 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Surveillance Brain MRI is the first listed.
NCT07357298 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07357298 about?
NCT07357298 is a clinical study titled "Phase III Trial of Brain MRI Surveillance in Stage IV Breast Cancer". This randomized, multi-institutional phase III trial evaluates whether routine surveillance brain MRI every 6 months improves detection and treatment characteristics of brain metastases in neurologically asymptomatic patients with stage IV breast cancer. Patients are stratified by receptor subtype, ...
What is the current status of trial NCT07357298?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 156 participants. The study started on 2026-02-25. Estimated completion is 2030-02.
What interventions are being tested in trial NCT07357298?
The interventions under investigation include: Surveillance Brain MRI (DIAGNOSTIC_TEST), Standard of Care Brain Imaging (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07357298?
This trial is sponsored by H. Lee Moffitt Cancer Center and Research Institute, which has 502 total clinical trials registered on ClinicalTrials.gov.
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