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NCT07337577 · ClinicalTrials.gov registry record · NA
Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure
A NA study, sponsored by Brigham and Women's Hospital.
- Not yet
- Registry status
- NA
- Development phase
- 500
- Enrollment target
NCT07337577 is a NA study that has not yet begun recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 500 participants.
The verdict
NCT07337577, a NA study, has not yet begun recruiting, sponsored by Brigham and Women's Hospital.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 500 participants
- Enrollment target
Study Summary
This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for adult patients with heart failure seen in outpatient cardiology clinics at Mass General Brigham. For eligible heart failure encounters, the CDS tool reviews existing electronic health record (EHR) data, including diagnoses, medications, vital signs, laboratory results, and recent notes, and generates brief, clinician-facing messages suggesting opportunities to initiate or optimize GDMT and highlighting relevant safety considerations. Messages are delivered to cardiology providers via Epic InBasket and/or institutional email prior to scheduled visits. The tool is advisory only and cannot place orders or change medications automatically; all treatment decisions remain at the discretion of the treating clinician and patient. Cardiology providers are assigned at the provider/clinic level to early implementation of the CDS tool versus usual care (no messages) during the initial phase. The primary outcome is GDMT optimization within 30 days of an index visit. Secondary outcomes include feasibility of CDS generation and delivery and a 30-day safety composite (e.g., heart failure hospitalization, acute kidney injury, hyperkalemia, hypotension or bradyarrhythmia plausibly related to GDMT).
Interventions
- DEVICE LLM-GDMT Clinical Decision Support Tool
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2026-06-01 |
| Est. Completion | 2027-12-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07337577
The ClinicalTrials.gov registry entry for NCT07337577 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 500 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which LLM-GDMT Clinical Decision Support Tool is the first listed.
NCT07337577 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07337577 about?
NCT07337577 is a clinical study titled "Large Language Model-Generated Messages to Improve Guideline-Directed Medical Therapy in Heart Failure". This study is an investigator-initiated, cluster-randomized implementation trial evaluating a large language model (LLM)-based clinical decision support (CDS) tool designed to improve guideline-directed medical therapy (GDMT) for adult patients with heart failure seen in outpatient cardiology clinic...
What is the current status of trial NCT07337577?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 500 participants. The study started on 2026-06-01. Estimated completion is 2027-12-01.
What interventions are being tested in trial NCT07337577?
The interventions under investigation include: LLM-GDMT Clinical Decision Support Tool (DEVICE).
Who is sponsoring clinical trial NCT07337577?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
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