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NCT07293650 · ClinicalTrials.gov registry record · Phase 3
PREcision MEDicine In Achalasia (PREMEDIA)
A Phase 3 study, sponsored by Northwestern University.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 372
- Enrollment target
NCT07293650: Recruiting Phase 3 study, sponsored by Northwestern University.
NCT07293650 is a Phase 3 study that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 372 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (52% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07293650, a Phase 3 study, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 372 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the esophagus work just as well as making the standard bigger cut in relieving symptoms? * Does making the smaller cut reduce the side effects of the procedure compared to the standard bigger cut? Researchers will compare the symptoms and side effects of making a shorter cut to the symptoms and side effects of a longer cut. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.
Primary Outcome
Clinical Response is defined by the Eckardt score (a 4-item self-report scale measuring weight loss, chest pain, regurgitation, and dysphagia) with no need for retreatment in 2 years.
Interventions
- PROCEDURE Standard Myotomy
- PROCEDURE Tailored Short Myotomy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 372 participants |
| Start Date | 2026-04-23 |
| Est. Completion | 2030-03-01 |
| Phase | Phase 3 |
What NCT07293650 shows while recruiting
NCT07293650 is an interventional study that assigns participants to a tested intervention. The registered 372 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (52% lower).
The record links to 0 conditions, and to 2 interventions - of which Standard Myotomy is the first listed.
NCT07293650 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07293650 about?
NCT07293650 is a clinical study titled "PREcision MEDicine In Achalasia (PREMEDIA)". The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the...
What is the current status of trial NCT07293650?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 372 participants. The study started on 2026-04-23. Estimated completion is 2030-03-01.
What interventions are being tested in trial NCT07293650?
The interventions under investigation include: Standard Myotomy (PROCEDURE), Tailored Short Myotomy (PROCEDURE).
Who is sponsoring clinical trial NCT07293650?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07293650's enrollment target sits among peer trials
372 991st of 2000 higher than 1,009 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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