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NCT07284654 · ClinicalTrials.gov registry record · Phase 3
Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Immunobridging to Adults 18-49
A Phase 3 study of Pneumococcal Vaccines, sponsored by Vaxcyte.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 4,000
- Enrollment target
- 20
- Study locations
NCT07284654: Recruiting Phase 3 study of Pneumococcal Vaccines, sponsored by Vaxcyte.
NCT07284654 is a Phase 3 study of Pneumococcal Vaccines that is actively recruiting participants, run by Vaxcyte. The registered enrollment target is 4,000 participants, above the 787-participant average among 5 other Pneumococcal Vaccines trials with a reported enrollment target (408% higher). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07284654, a Phase 3 study of Pneumococcal Vaccines, is actively recruiting participants, sponsored by Vaxcyte.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 4,000 participants
- Enrollment target
- 20
- Study locations
Study Summary
The primary objectives of this study are to evaluate the safety, tolerability, immunologic noninferiority (for shared serotypes) and immunologic superiority (for novel serotypes) of VAX-31 compared to PCV21 and PCV20 in adults ≥50 years of age, and to bridge the immune responses induced by VAX-31 in adults 50-64 years of age to adults 18-49 years of age.
Conditions Studied
Interventions
- BIOLOGICAL PCV21
- BIOLOGICAL 31 valent pneumococcal conjugate vaccine
- BIOLOGICAL PCV20
Study Locations (20)
Florida
- Research Centers of America - Hollywood - CenExel - Hollywood
- Health Awareness - Jupiter - ERN - Jupiter
- Suncoast Research Group LLC - Miami
- Precision Clinical Research - Sunrise - Sunrise
Arizona
- Center for Indigenous Health - Chinle - Johns Hopkins Project - Chinle
- Center for Indigineous Health - Whiteriver - John Hopkins Project - Whiteriver
Kansas
- Johnson County Clin-Trials - JCCT - Lenexa
- Alliance for Multispecialty Research, LLC - West Wichita - Wichita
Mississippi
- DelRicht Research, LLC - Gulfport - Gulfport
- Sky Integrative Medical Center - SKYCRNG - Ridgeland
Alabama
- Accel Research Site - Achieve - Birmingham - ERN - Birmingham
California
- Clinical Innovations Trials - Riverside - CenExel - Riverside
Georgia
- Clinical Research Atlanta - Headlands - Stockbridge
Indiana
- Velocity Clinical Research - Valparaiso (Buynak Clinical Research) - Valparaiso
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4,000 participants |
| Start Date | 2025-12-01 |
| Est. Completion | 2027-01 |
| Phase | Phase 3 |
What NCT07284654 shows while recruiting
NCT07284654 is an interventional study that assigns participants to a tested intervention. Its 4,000 participants enrollment target places it among the larger protocols in the corpus, above the 787-participant average among 5 other Pneumococcal Vaccines trials with a reported enrollment target (408% higher).
The record links to 1 condition, with Pneumococcal Vaccines appearing as the primary indexed condition, and to 3 interventions - of which PCV21 is the first listed.
NCT07284654 names 20 study sites across 14 states, led by Florida, Arizona, Kansas.
Frequently Asked Questions
What is clinical trial NCT07284654 about?
NCT07284654 is a clinical study titled "Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Immunobridging to Adults 18-49". The primary objectives of this study are to evaluate the safety, tolerability, immunologic noninferiority (for shared serotypes) and immunologic superiority (for novel serotypes) of VAX-31 compared to PCV21 and PCV20 in adults ≥50 years of age, and to bridge the immune responses induced by VAX-31 in...
What is the current status of trial NCT07284654?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 4,000 participants. The study started on 2025-12-01. Estimated completion is 2027-01.
What conditions does trial NCT07284654 study?
This clinical trial studies the following conditions: Pneumococcal Vaccines.
What interventions are being tested in trial NCT07284654?
The interventions under investigation include: PCV21 (BIOLOGICAL), 31 valent pneumococcal conjugate vaccine (BIOLOGICAL), PCV20 (BIOLOGICAL).
Who is sponsoring clinical trial NCT07284654?
This trial is sponsored by Vaxcyte, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07284654 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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