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NCT07258784 · ClinicalTrials.gov registry record
RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis
A clinical trial of Tracheal Stenosis and Subglottic Stenosis, sponsored by University of Maryland, Baltimore.
- Recruiting
- Registry status
- 10
- Enrollment target
- 1
- Study location
NCT07258784: Recruiting study of Tracheal Stenosis and Subglottic Stenosis, sponsored by University of Maryland, Baltimore.
NCT07258784 is a study of Tracheal Stenosis and Subglottic Stenosis that is actively recruiting participants, run by University of Maryland, Baltimore. The registered enrollment target is 10 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07258784, a study of Tracheal Stenosis and Subglottic Stenosis, is actively recruiting participants, sponsored by University of Maryland, Baltimore.
- RECRUITING
- Registry status
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.
Primary Outcome
The diseased mucosa will show a increased fibrosis and inflammation profile compared with that from normal mucosa
Conditions Studied
Interventions
- PROCEDURE Biopsy or surgery
Study Locations (1)
Maryland
- University of Maryland - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2025-09-11 |
| Est. Completion | 2026-12-31 |
What NCT07258784 shows while recruiting
NCT07258784 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 10 participants, a relatively small participant target.
The record links to 2 conditions, with Tracheal Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Biopsy or surgery is the first listed.
NCT07258784 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT07258784 about?
NCT07258784 is a clinical study titled "RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis". Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endo...
What is the current status of trial NCT07258784?
This trial is currently recruiting. The enrollment target is 10 participants. The study started on 2025-09-11. Estimated completion is 2026-12-31.
What conditions does trial NCT07258784 study?
This clinical trial studies the following conditions: Tracheal Stenosis, Subglottic Stenosis.
What interventions are being tested in trial NCT07258784?
The interventions under investigation include: Biopsy or surgery (PROCEDURE).
Who is sponsoring clinical trial NCT07258784?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07258784 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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