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NCT07244419 · ClinicalTrials.gov registry record · Early Phase 1
Prevention of Graft Rejection in Hematopoietic Stem Cell Transplant (HSCT) Recipients
A Early Phase 1 study of Hematopoietic Stem Cell Transplantation and Graft Failure, sponsored by Children's Hospital Medical Center, Cincinnati.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07244419: Recruiting Early Phase 1 study of Hematopoietic Stem Cell Transplantation and Graft Failure, sponsored by Children's Hospital Medical Center, Cincinnati.
NCT07244419 is a Early Phase 1 study of Hematopoietic Stem Cell Transplantation and Graft Failure that is actively recruiting participants, run by Children's Hospital Medical Center, Cincinnati. The registered enrollment target is 20 participants, below the 9,789-participant average among 26 other Hematopoietic Stem Cell Transplantation trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07244419, a Early Phase 1 study of Hematopoietic Stem Cell Transplantation and Graft Failure, is actively recruiting participants, sponsored by Children's Hospital Medical Center, Cincinnati.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators hypothesize that graft rejection after hematopoietic stem cell transplant (HSCT) is primarily driven by interferon gamma, and prophylactic interferon gamma inhibition in high-risk patients will prevent graft rejection. Additionally, knowledge of emapalumab PK/PD and in vitro mechanistic effects of emapalumab in this novel setting will guide optimization of dosing regimens and treatment approaches in future studies.
Primary Outcome
Measured by the incidence of graft rejection in the treatment cohort.
Conditions Studied
Interventions
- DRUG Emapalumab 3 mg/kg
- DRUG Emapalumab 10 mg/kg
Study Locations (1)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-01-07 |
| Est. Completion | 2029-08 |
| Phase | Early Phase 1 |
What NCT07244419 shows while recruiting
NCT07244419 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 9,789-participant average among 26 other Hematopoietic Stem Cell Transplantation trials with a reported enrollment target (100% lower).
The record links to 2 conditions, with Hematopoietic Stem Cell Transplantation appearing as the primary indexed condition, and to 2 interventions - of which Emapalumab 3 mg/kg is the first listed.
NCT07244419 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07244419 about?
NCT07244419 is a clinical study titled "Prevention of Graft Rejection in Hematopoietic Stem Cell Transplant (HSCT) Recipients". The investigators hypothesize that graft rejection after hematopoietic stem cell transplant (HSCT) is primarily driven by interferon gamma, and prophylactic interferon gamma inhibition in high-risk patients will prevent graft rejection. Additionally, knowledge of emapalumab PK/PD and in vitro mechan...
What is the current status of trial NCT07244419?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2026-01-07. Estimated completion is 2029-08.
What conditions does trial NCT07244419 study?
This clinical trial studies the following conditions: Hematopoietic Stem Cell Transplantation, Graft Failure.
What interventions are being tested in trial NCT07244419?
The interventions under investigation include: Emapalumab 3 mg/kg (DRUG), Emapalumab 10 mg/kg (DRUG).
Who is sponsoring clinical trial NCT07244419?
This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 571 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07244419 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07244419's enrollment target sits among peer trials
20 22nd of 26 higher than 3 of 26 other Hematopoietic Stem Cell Transplantation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hematopoietic Stem Cell Transplantation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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