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NCT07225348 · ClinicalTrials.gov registry record · Phase 4
Treatment of Perioral Wrinkles Using Topical Poly-L-lactic Acid and Microneedling Device
A Phase 4 study of Perioral Wrinkles, sponsored by Skincare Physicians of Chestnut Hill.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT07225348: Recruiting Phase 4 study of Perioral Wrinkles, sponsored by Skincare Physicians of Chestnut Hill.
NCT07225348 is a Phase 4 study of Perioral Wrinkles that is actively recruiting participants, run by Skincare Physicians of Chestnut Hill. The registered enrollment target is 26 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07225348, a Phase 4 study of Perioral Wrinkles, is actively recruiting participants, sponsored by Skincare Physicians of Chestnut Hill.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
The first goal of this clinical trial is to learn if topical application of PLLA in conjunction with a microneedling treatment works to treat perioral wrinkles in adults. The second goal is to see whether the application of topical PLLA is more effective before or after a microneedling treatment. The main questions it aims to answer are: * Is PLLA present within the MN channels from in vivo biopsy samples? * Is it safe to combine topical PLLA and MN in the treatment of perioral wrinkles, as determined by the incidence and severity of adverse events in healthy subjects? * Does overall aesthetic and skin texture improve in combining microneedling with topical PLLA in the treatment of mild to moderate perioral wrinkles? * Is it the treatment of topical PLLA more effective when applied before or after a microneedling treatment. Researchers will compare the application of PLLA before a microneedling treatment to a microneedling treatment with PLLA application after to see which treatment method is more effective. Participants will: \- receive 2 treatments spaced 4-6 weeks apart of topical PLLA and microneedling
Primary Outcome
blinded in person GAIS scores
Conditions Studied
Interventions
- DRUG Poly-L-Lactic Acid
- DEVICE Microneedling
Study Locations (1)
Massachusetts
- SkinCare Physicians - Chestnut Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2025-11-07 |
| Est. Completion | 2026-10-01 |
| Phase | Phase 4 |
What NCT07225348 shows while recruiting
NCT07225348 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Perioral Wrinkles appearing as the primary indexed condition, and to 2 interventions - of which Poly-L-Lactic Acid is the first listed.
NCT07225348 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07225348 about?
NCT07225348 is a clinical study titled "Treatment of Perioral Wrinkles Using Topical Poly-L-lactic Acid and Microneedling Device". The first goal of this clinical trial is to learn if topical application of PLLA in conjunction with a microneedling treatment works to treat perioral wrinkles in adults. The second goal is to see whether the application of topical PLLA is more effective before or after a microneedling treatment. Th...
What is the current status of trial NCT07225348?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 26 participants. The study started on 2025-11-07. Estimated completion is 2026-10-01.
What conditions does trial NCT07225348 study?
This clinical trial studies the following conditions: Perioral Wrinkles.
What interventions are being tested in trial NCT07225348?
The interventions under investigation include: Poly-L-Lactic Acid (DRUG), Microneedling (DEVICE).
Who is sponsoring clinical trial NCT07225348?
This trial is sponsored by Skincare Physicians of Chestnut Hill, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07225348 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07225348's enrollment target sits among peer trials
26 1655th of 2000 higher than 333 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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