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NCT07224854 · ClinicalTrials.gov registry record
Epigenetic Signature for CRC Early Detection
A clinical trial of Early Detection of Cancer and Cell-free DNA, sponsored by City of Hope Medical Center.
- Active
- Registry status
- 500
- Enrollment target
- 1
- Study location
NCT07224854 is a study of Early Detection of Cancer and Cell-free DNA that is active but no longer recruiting, run by City of Hope Medical Center. The registered enrollment target is 500 participants, below the 37,703-participant average among 8 other Early Detection of Cancer trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07224854, a study of Early Detection of Cancer and Cell-free DNA, is active but no longer recruiting, sponsored by City of Hope Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- 500 participants
- Enrollment target
- 1
- Study location
Study Summary
The epiCED is a noninvasive blood-based assay designed for early detection of colorectal cancer (CRC) using circulating cell-free DNA (cfDNA) 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) epigenetic markers. This study leverages retrospective, multi-center cohorts of CRC patients and non-cancer controls to discover and validate a robust cfDNA methylation signature. Small-scale sequencing and machine learning-based modeling will be applied to identify a minimal panel of methylation markers that can accurately discriminate CRC from non-cancer individuals, including early-stage disease. The ultimate goal is to develop a clinically practical, noninvasive screening tool that enables population-level early detection and improves patient outcomes.
Conditions Studied
Study Locations (1)
California
- City of Hope Nat Medical Ctr - Monrovia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2024-06-21 |
| Est. Completion | 2026-06-18 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07224854
The ClinicalTrials.gov registry entry for NCT07224854 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 500 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 37,703-participant average among 8 other Early Detection of Cancer trials with a reported enrollment target (99% lower). The listed sponsor is City of Hope Medical Center, which has 582 total studies on file at ClinicalTrials.gov.
The record links to 5 conditions, with Early Detection of Cancer appearing as the primary indexed condition, and to 0 interventions.
NCT07224854 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT07224854 about?
NCT07224854 is a clinical study titled "Epigenetic Signature for CRC Early Detection". The epiCED is a noninvasive blood-based assay designed for early detection of colorectal cancer (CRC) using circulating cell-free DNA (cfDNA) 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) epigenetic markers. This study leverages retrospective, multi-center cohorts of CRC patients and non...
What is the current status of trial NCT07224854?
This trial is currently active not recruiting. The enrollment target is 500 participants. The study started on 2024-06-21. Estimated completion is 2026-06-18.
What conditions does trial NCT07224854 study?
This clinical trial studies the following conditions: Early Detection of Cancer, Cell-free DNA, Colorectal Cancer (Diagnosis), Non-cancer Controls, DNA Methylation.
Who is sponsoring clinical trial NCT07224854?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07224854 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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