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NCT07218068 · ClinicalTrials.gov registry record · Early Phase 1
Intensive Preventative Dental Program Pilot Study
A Early Phase 1 study, sponsored by Wake Forest University Health Sciences.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 13
- Enrollment target
NCT07218068: Completed Early Phase 1 study, sponsored by Wake Forest University Health Sciences.
NCT07218068 is a Early Phase 1 study that has completed, run by Wake Forest University Health Sciences. The registered enrollment target is 13 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (75% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07218068, a Early Phase 1 study, has completed, sponsored by Wake Forest University Health Sciences.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 13 participants
- Enrollment target
Study Summary
Radiation therapy to treat cancer may cause a dry mouth from damage to salivary glands which may increase the risk of cavities on the teeth. The consistent use of prescription fluoride on teeth after radiation therapy for head and neck cancer may reduce the development of cavities and tooth loss. The purpose of this study is to find out if prescription fluoride varnish applied to the teeth every three months during the first year after radiation therapy changes the development of cavities or gum problems.
Primary Outcome
Decayed, Missing and Filled Surfaces Score (DMFS) is calculated by a calibrated oral examiner as the combined number of of decayed, missing, and/or filled tooth surfaces, from the baseline dental visit DMFS score before starting radiotherapy to the final dental visit DMFS score 12 months following completion of radiation therapy.
Interventions
- DRUG Fluoride varnish
- OTHER Regular Care
- OTHER Medical Oncology Care Team
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2021-10-19 |
| Est. Completion | 2024-07-10 |
| Phase | Early Phase 1 |
What the finished NCT07218068 record still lists
NCT07218068 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (75% lower).
The record links to 0 conditions, and to 3 interventions - of which Fluoride varnish is the first listed.
NCT07218068 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07218068 about?
NCT07218068 is a clinical study titled "Intensive Preventative Dental Program Pilot Study". Radiation therapy to treat cancer may cause a dry mouth from damage to salivary glands which may increase the risk of cavities on the teeth. The consistent use of prescription fluoride on teeth after radiation therapy for head and neck cancer may reduce the development of cavities and tooth loss. Th...
What is the current status of trial NCT07218068?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 13 participants. The study started on 2021-10-19. Estimated completion is 2024-07-10.
What interventions are being tested in trial NCT07218068?
The interventions under investigation include: Fluoride varnish (DRUG), Regular Care (OTHER), Medical Oncology Care Team (OTHER).
Who is sponsoring clinical trial NCT07218068?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07218068's enrollment target sits among peer trials
13 1504th of 2000 higher than 472 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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