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RECRUITING Phase 2

A Study of KT-621 Administered Orally to Participants With Moderate to Severe Atopic Dermatitis

NCT07217015 · View on ClinicalTrials.gov ↗

Study Summary

This phase 2b study is designed to evaluate the safety and efficacy of KT-621 in adult and adolescent participants with moderate-to-severe atopic dermatitis (AD), a common form of eczema. The main goals of this study are to learn how effective KT-621 is at reducing the severity and extent of AD, the safety and tolerability of KT-621, how KT-621 behaves in the body, and how the body responds to KT-621. This is a 16-week double-blind, placebo-controlled study with a 52-week open-label period.

Conditions Studied

Interventions

  • OTHER Placebo
  • DRUG KT-621

Study Locations (20)

California

  • Kymera Investigative Site — Freemont
  • Kymera Investigative Site — Los Angeles
  • Kymera Investigative Site — Santa Monica

Florida

  • Kymera Investigative Site — Delray Beach
  • Kymera Investigative Site — Miami
  • Kymera Investigative Site — Miramar

Michigan

  • Kymera Investigative Site — Ann Arbor
  • Kymera Investigative Site — Detroit

Texas

  • Kymera Investigative Site — San Antonio
  • Kymera Investigative Site — San Antonio

New South Wales

  • Kymera Investigative Site — Darlinghurst
  • Kymera Investigative Site — Kogarah

Alabama

  • Kymera Investigative Site — Birmingham

Arkansas

  • Kymera Investigative Site — North Little Rock

Illinois

  • Kymera Investigative Site — Normal

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2025-11-24
Est. Completion 2028-06
Phase Phase 2

Sponsor

Kymera Therapeutics

5 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07217015

The ClinicalTrials.gov registry entry for NCT07217015 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kymera Therapeutics, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Atopic Dermatitis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07217015 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Florida, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07217015 about?

NCT07217015 is a clinical study titled "A Study of KT-621 Administered Orally to Participants With Moderate to Severe Atopic Dermatitis". This phase 2b study is designed to evaluate the safety and efficacy of KT-621 in adult and adolescent participants with moderate-to-severe atopic dermatitis (AD), a common form of eczema. The main goals of this study are to learn how effective KT-621 is at reducing the severity and extent of AD, the...

What is the current status of trial NCT07217015?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 200 participants. The study started on 2025-11-24. Estimated completion is 2028-06.

What conditions does trial NCT07217015 study?

This clinical trial studies the following conditions: Atopic Dermatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07217015?

The interventions under investigation include: Placebo (OTHER), KT-621 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07217015?

This trial is sponsored by Kymera Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07217015 being conducted?

This trial has 20 study locations across Alabama, Arkansas, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial