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NCT07188376 · ClinicalTrials.gov registry record · NA
Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation
A NA study of Alcohol Risk Behaviors, sponsored by Michael J. Wesley, PhD.
- Recruiting
- Registry status
- NA
- Development phase
- 12
- Enrollment target
- 1
- Study location
NCT07188376: Recruiting NA study of Alcohol Risk Behaviors, sponsored by Michael J. Wesley, PhD.
NCT07188376 is a NA study of Alcohol Risk Behaviors that is actively recruiting participants, run by Michael J. Wesley, PhD. The registered enrollment target is 12 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07188376, a NA study of Alcohol Risk Behaviors, is actively recruiting participants, sponsored by Michael J. Wesley, PhD.
- RECRUITING
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to learn how a specific type of brain stimulation affects alcohol-related decision-making and self-control in adults who drink alcohol. The main questions the study aims to answer are: * Does brain stimulation change how people behave after drinking alcohol? * Does the combination of alcohol and different types of brain stimulation affect people's ability to make thoughtful decisions or resist impulses? Researchers will compare the effects of two types of brain stimulation, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), after people drink alcohol or a placebo drink. A sham (placebo) stimulation condition will also be included. The study uses a within-person design, which means each participant will take part in all conditions. Participants will: * Attend five separate study visits * Drink either an alcoholic or placebo beverage * Receive one of the brain stimulation conditions (real or sham) * Complete decision-making tasks before and after drinking The tasks will measure things like impulsive choices and reaction time. The researchers hope this study will help identify how brain stimulation could be used to improve decision-making during intoxication, which might one day reduce harmful drinking behaviors or prevent alcohol-related accidents.
Primary Outcome
Change in the proportion of inhibition failures (p-failures) on the cued Go/NoGo task from baseline to post-intervention under each experimental condition. Higher p-failure rates reflect poorer inhibitory control. This outcome will be measured following each TMS and alcohol condition (iTBS, cTBS, sham × active or placebo alcohol), and assessed across timepoints (peak Blood Alcohol Concentration (BAC) \~0.08% and descending BAC \~0.05%).
Conditions Studied
Interventions
- DEVICE Intermittent Theta Burst Stimulation
- DEVICE Continuous Theta Burst Stimulation
- DEVICE Sham Transcranial Magnetic Stimulation
Study Locations (1)
Kentucky
- University of Kentucky - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2025-10-30 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What NCT07188376 shows while recruiting
NCT07188376 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Alcohol Risk Behaviors appearing as the primary indexed condition, and to 3 interventions - of which Intermittent Theta Burst Stimulation is the first listed.
NCT07188376 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT07188376 about?
NCT07188376 is a clinical study titled "Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation". The goal of this clinical trial is to learn how a specific type of brain stimulation affects alcohol-related decision-making and self-control in adults who drink alcohol. The main questions the study aims to answer are: * Does brain stimulation change how people behave after drinking alcohol? * Doe...
What is the current status of trial NCT07188376?
This trial is currently recruiting. It is a NA study. The enrollment target is 12 participants. The study started on 2025-10-30. Estimated completion is 2026-12-01.
What conditions does trial NCT07188376 study?
This clinical trial studies the following conditions: Alcohol Risk Behaviors.
What interventions are being tested in trial NCT07188376?
The interventions under investigation include: Intermittent Theta Burst Stimulation (DEVICE), Continuous Theta Burst Stimulation (DEVICE), Sham Transcranial Magnetic Stimulation (DEVICE).
Who is sponsoring clinical trial NCT07188376?
This trial is sponsored by Michael J. Wesley, PhD, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07188376 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07188376's enrollment target sits among peer trials
12 1913th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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