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NCT07177417 · ClinicalTrials.gov registry record · Phase 4
Characterizing the Human Airway Immune Response to FluMist Vaccination
A Phase 4 study of Healthy Young Adults and Influenza Vaccines, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07177417 is a Phase 4 study of Healthy Young Adults and Influenza Vaccines that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 30 participants, below the 66-participant average among 4 other Healthy Young Adults trials with a reported enrollment target (55% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07177417, a Phase 4 study of Healthy Young Adults and Influenza Vaccines, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine. The study will evaluate immune responses in groups of healthy, non-pregnant, volunteers between the ages of 18 and 40. The main purpose of the study is to measure the change in influenza vaccine-specific antibodies in the lower lungs and nose between vaccination and 14 days after participants receive the vaccine. All participants will be randomized to receive one of the two seasonal flu vaccines and will have blood and back of the nose swabs collected throughout the study. Some study participants will choose to undergo optional bronchoscopy procedures and will be included in the part of the study looking at lower lung immune responses.
Conditions Studied
Interventions
- BIOLOGICAL FluMist
- BIOLOGICAL inactivated influenza vaccine
- PROCEDURE bronchoscopy
Study Locations (1)
Missouri
- Washington University in Saint Louis School of Medicine Emergency Care and Research Core - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-09-09 |
| Est. Completion | 2028-11 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07177417
The ClinicalTrials.gov registry entry for NCT07177417 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 66-participant average among 4 other Healthy Young Adults trials with a reported enrollment target (55% lower). The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Healthy Young Adults appearing as the primary indexed condition, and to 3 interventions - of which FluMist is the first listed.
NCT07177417 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.
Frequently Asked Questions
What is clinical trial NCT07177417 about?
NCT07177417 is a clinical study titled "Characterizing the Human Airway Immune Response to FluMist Vaccination". The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine. The study will evaluate immune responses in groups of healthy, non-pregnant...
What is the current status of trial NCT07177417?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 30 participants. The study started on 2025-09-09. Estimated completion is 2028-11.
What conditions does trial NCT07177417 study?
This clinical trial studies the following conditions: Healthy Young Adults, Influenza Vaccines, Influenza Vaccine Response.
What interventions are being tested in trial NCT07177417?
The interventions under investigation include: FluMist (BIOLOGICAL), inactivated influenza vaccine (BIOLOGICAL), bronchoscopy (PROCEDURE).
Who is sponsoring clinical trial NCT07177417?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07177417 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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