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RECRUITING Phase 3

A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

NCT07169578 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment \[MCI\] to mild dementia due to AD).

Conditions Studied

Interventions

  • OTHER Placebo
  • DRUG Trontinemab

Study Locations (20)

Florida

  • K2 Medical Research - The Villages — Lady Lake
  • K2 Medical Research, LLC — Maitland
  • Renstar Medical Research — Ocala
  • Axiom Brain Health LLC — Tampa
  • Charter Research - Lady Lake/The Villages — The Villages
  • Alzheimer?s Research and Treatment Center — Wellington
  • Conquest Research, LLC — Winter Park

California

  • Inglewood Clinicals — Inglewood
  • Irvine Center for Clinical Research — Irvine
  • UCSF - Memory and Aging Center — San Francisco
  • Syrentis Clinical Research — Santa Ana

New York

  • Basil Clinical — Laurelton
  • Adams Clinical Harlem — New York

Arizona

  • Banner Sun Health Research Institute — Sun City

Georgia

  • Accel Research Sites-NeuroStudies — Decatur

Hawaii

  • Hawaii Pacific Neuroscience — Honolulu

Illinois

  • RE:Cognition (Chicago) — Chicago

Massachusetts

  • Boston Center for Memory — Newton

Trial Details

FieldValue
Enrollment Target 800 participants
Start Date 2025-09-17
Est. Completion 2028-06-07
Phase Phase 3

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07169578

The ClinicalTrials.gov registry entry for NCT07169578 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 800 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Alzheimers Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07169578 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07169578 about?

NCT07169578 is a clinical study titled "A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease". The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment \[MCI\] to mild dementia due to AD).

What is the current status of trial NCT07169578?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 800 participants. The study started on 2025-09-17. Estimated completion is 2028-06-07.

What conditions does trial NCT07169578 study?

This clinical trial studies the following conditions: Alzheimers Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07169578?

The interventions under investigation include: Placebo (OTHER), Trontinemab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07169578?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07169578 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Hawaii. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial