Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07166289 · ClinicalTrials.gov registry record · NA
Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
A NA study of Treatment-Resistant Depression, sponsored by Laureate Institute for Brain Research.
- Recruiting
- Registry status
- NA
- Development phase
- 140
- Enrollment target
- 1
- Study location
NCT07166289 is a NA study of Treatment-Resistant Depression that is actively recruiting participants, run by Laureate Institute for Brain Research. The registered enrollment target is 140 participants, below the 371-participant average among 54 other Treatment-Resistant Depression trials with a reported enrollment target (62% lower). The trial reports 1 study location across 1 state.
The verdict
NCT07166289, a NA study of Treatment-Resistant Depression, is actively recruiting participants, sponsored by Laureate Institute for Brain Research.
- RECRUITING
- Registry status
- NA
- Development phase
- 140 participants
- Enrollment target
- 1
- Study location
Study Summary
Approximately one third of individuals with Major Depressive Disorder (MDD) are considered treatment-resistant, subject to severe disability and risk of suicide, and exhibit symptoms anchored in abnormalities of Research Domain Criteria (RDoC) Negative Valence Systems behavioral processes. In the present study we plan to use low-intensity focused ultrasound in 120 persons with treatment-resistant MDD to modulate deep white matter tracts connecting the thalamus and different regions of the prefrontal cortex reversibly and non-invasively, with the aim of assigning a causal, mechanistic role to large scale brain circuits in the production of those critical behavioral abnormalities. A successful study will help to attain the precise definition of neuromodulation targets for this clinical population in utter need of help.
Conditions Studied
Interventions
- OTHER Low-intensity focused ultrasound
Study Locations (1)
Oklahoma
- Laureate Institute for Brain Research - Tulsa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 140 participants |
| Start Date | 2025-09-30 |
| Est. Completion | 2030-07 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07166289
The ClinicalTrials.gov registry entry for NCT07166289 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 140 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 371-participant average among 54 other Treatment-Resistant Depression trials with a reported enrollment target (62% lower). The listed sponsor is Laureate Institute for Brain Research, which has 45 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Treatment-Resistant Depression appearing as the primary indexed condition, and to 1 intervention - of which Low-intensity focused ultrasound is the first listed.
NCT07166289 reports 1 study location spanning 1 distinct geographic area - top geographies include Oklahoma.
Frequently Asked Questions
What is clinical trial NCT07166289 about?
NCT07166289 is a clinical study titled "Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression". Approximately one third of individuals with Major Depressive Disorder (MDD) are considered treatment-resistant, subject to severe disability and risk of suicide, and exhibit symptoms anchored in abnormalities of Research Domain Criteria (RDoC) Negative Valence Systems behavioral processes. In the pr...
What is the current status of trial NCT07166289?
This trial is currently recruiting. It is a NA study. The enrollment target is 140 participants. The study started on 2025-09-30. Estimated completion is 2030-07.
What conditions does trial NCT07166289 study?
This clinical trial studies the following conditions: Treatment-Resistant Depression.
What interventions are being tested in trial NCT07166289?
The interventions under investigation include: Low-intensity focused ultrasound (OTHER).
Who is sponsoring clinical trial NCT07166289?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07166289 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Treatment-Resistant Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
RECRUITING · NA
-
DBS for TRD With the Medtronic Percept PC
RECRUITING · NA
-
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
RECRUITING · NA
-
PCS in Severe Treatment Resistant Depression
RECRUITING · NA
-
Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
RECRUITING · NA
-
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
RECRUITING · NA
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.