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NCT07166172 · ClinicalTrials.gov registry record · NA

Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH

A NA study of Congenital Diaphragmatic Hernia and Hernia, sponsored by Johns Hopkins University.

Recruiting
Registry status
NA
Development phase
80
Enrollment target
1
Study location

NCT07166172: Recruiting NA study of Congenital Diaphragmatic Hernia and Hernia, sponsored by Johns Hopkins University.

NCT07166172 is a NA study of Congenital Diaphragmatic Hernia and Hernia that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 80 participants, below the 193-participant average among 22 other Congenital Diaphragmatic Hernia trials with a reported enrollment target (59% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT07166172, a NA study of Congenital Diaphragmatic Hernia and Hernia, is actively recruiting participants, sponsored by Johns Hopkins University.

RECRUITING
Registry status
NA
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to evaluate successful placement and removal of Fetoscopic Endoluminal Tracheal Occlusion (FETO) device in cases of intrathoracic liver herniation with isolated left congenital diaphragmatic hernia (LCDH) with Observed/Expected (O/E) Lung to Head Circumference Ratio (LHR) \< 30% or isolated right congenital diaphragmatic hernia (RCDH) with O/E LHR \< 45%,to compare survival to discharge from the neonatal intensive care units (NICU), between fetuses with intrathoracic liver herniation and isolated LCDH with O/E LHR \< 30% that receive FETO procedure performed at 27 weeks 0 days to 29weeks 6 days of gestation to those with intrathoracic liver herniation, isolated LCDH and o/e LRH \< 30% that undergo expectant management, to compare the neonatal survival rate to discharge from the neonatal intensive care units (NICU), between fetuses with intrathoracic liver herniation, isolated RCHD with o/e LHR \< 45% that undergo FETO procedure performed at 27 weeks 0 days to 29 weeks 6 days gestation to those with intrathoracic liver herniation, isolated RCHD and o/e LHR \< 45% that elect to proceed with expectant management, to evaluate the frequency of maternal and fetal complications associated with FETO procedure, to evaluate whether the FETO procedure is associated with reduced long-term mortality and morbidities in isolated LCDH survivors with o/e LHR \<30% when compared to isolated LCDH with o/e LRH \<30% that undergo expectant management where all fetuses were found to have intrathoracic liver herniation and to evaluate whether the FETO procedure is associated with reduced long-term mortality and morbidities in isolated RCDH survivors with o/e LHR ≤ 45% when compared to isolated RCHD with LHR \< 45% that undergo expectant management where all fetuses were found to have intrathoracic liver herniation.

Conditions Studied

Congenital Diaphragmatic Hernia Hernia Congenital Abnormalities Pathological Conditions, Anatomical Internal Hernia Hernia, DIaphragmatic, Congenital Neonatal Diseases and Abnormalities Pathological Conditions, Signs and Symptoms

Interventions

  • DEVICE Fetal Treatment Arm (FETO Group)

Study Locations (1)

Maryland

  • Johns Hopkins Hospital - Baltimore

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2025-06-23
Est. Completion 2031-12-01
Phase NA
Johns Hopkins University

1,448 total trials

What NCT07166172 shows while recruiting

NCT07166172 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 193-participant average among 22 other Congenital Diaphragmatic Hernia trials with a reported enrollment target (59% lower).

The record links to 8 conditions, with Congenital Diaphragmatic Hernia appearing as the primary indexed condition, and to 1 intervention - of which Fetal Treatment Arm (FETO Group) is the first listed.

NCT07166172 reports a single indexed study location in Maryland.

Frequently Asked Questions

What is clinical trial NCT07166172 about?

NCT07166172 is a clinical study titled "Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH". The purpose of this study is to evaluate successful placement and removal of Fetoscopic Endoluminal Tracheal Occlusion (FETO) device in cases of intrathoracic liver herniation with isolated left congenital diaphragmatic hernia (LCDH) with Observed/Expected (O/E) Lung to Head Circumference Ratio (LHR...

What is the current status of trial NCT07166172?

This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2025-06-23. Estimated completion is 2031-12-01.

What conditions does trial NCT07166172 study?

This clinical trial studies the following conditions: Congenital Diaphragmatic Hernia, Hernia, Congenital Abnormalities, Pathological Conditions, Anatomical, Internal Hernia.

What interventions are being tested in trial NCT07166172?

The interventions under investigation include: Fetal Treatment Arm (FETO Group) (DEVICE).

Who is sponsoring clinical trial NCT07166172?

This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07166172 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Congenital Diaphragmatic Hernia

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT07166172's enrollment target sits among peer trials

80 3rd of 22 higher than 17 of 22 other Congenital Diaphragmatic Hernia trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Congenital Diaphragmatic Hernia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT07166172

Source: ClinicalTrials.gov NCT07166172, the US trial registry maintained by the National Library of Medicine. NCT07166172 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.