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NCT07150806 · ClinicalTrials.gov registry record · Phase 1
RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma
A Phase 1 study of Recurrent Meningioma, sponsored by Joshua Palmer.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07150806: Recruiting Phase 1 study of Recurrent Meningioma, sponsored by Joshua Palmer.
NCT07150806 is a Phase 1 study of Recurrent Meningioma that is actively recruiting participants, run by Joshua Palmer. The registered enrollment target is 30 participants, below the 48-participant average among 6 other Recurrent Meningioma trials with a reported enrollment target (37% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07150806, a Phase 1 study of Recurrent Meningioma, is actively recruiting participants, sponsored by Joshua Palmer.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I/II tests the safety, side effects, best dose and how well giving RYZ101 works for the treatment of patients with intracranial meningioma that is growing, spreading, or getting worse (progressive) or that has come back after a period of improvement (recurrent). RYZ101 is a radioactive drug. It binds to a protein called somatostatin receptor, which is found on some neuroendocrine tumor cells. Lutetium Lu 177-dotatate builds up in these cells and gives off radiation that may kill them. It is a type of radioconjugate and a type of somatostatin analog. Giving RYZ101 may be safe, tolerable and/or effective in treating patients with progressive or recurrent intracranial meningioma.
Primary Outcome
Defined as survival without progression of disease (progressive disease, based on Response Assessment in Neuro-Oncology Criteria \[RANO\] 2.0 criteria) or death. Kaplan-Meier analyses will be used to estimate PFS.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- PROCEDURE Computed Tomography
- PROCEDURE Echocardiography Test
- RADIATION Gallium Ga 68-DOTATATE
- DRUG Actinium Ac 225 DOTATATE RYZ101
Study Locations (1)
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-11-12 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
What NCT07150806 shows while recruiting
NCT07150806 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 48-participant average among 6 other Recurrent Meningioma trials with a reported enrollment target (37% lower).
The record links to 1 condition, with Recurrent Meningioma appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT07150806 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT07150806 about?
NCT07150806 is a clinical study titled "RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma". This phase I/II tests the safety, side effects, best dose and how well giving RYZ101 works for the treatment of patients with intracranial meningioma that is growing, spreading, or getting worse (progressive) or that has come back after a period of improvement (recurrent). RYZ101 is a radioactive dr...
What is the current status of trial NCT07150806?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2025-11-12. Estimated completion is 2026-12-31.
What conditions does trial NCT07150806 study?
This clinical trial studies the following conditions: Recurrent Meningioma.
What interventions are being tested in trial NCT07150806?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Computed Tomography (PROCEDURE), Echocardiography Test (PROCEDURE), Gallium Ga 68-DOTATATE (RADIATION), Actinium Ac 225 DOTATATE RYZ101 (DRUG).
Who is sponsoring clinical trial NCT07150806?
This trial is sponsored by Joshua Palmer, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07150806 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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