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NCT07150091 · ClinicalTrials.gov registry record · Phase 1

Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMM

A Phase 1 study of Multiple Myeloma, sponsored by GlaxoSmithKline.

Active
Registry status
Phase 1
Development phase
20
Enrollment target
12
Study locations

NCT07150091 is a Phase 1 study of Multiple Myeloma that is active but no longer recruiting, run by GlaxoSmithKline. The registered enrollment target is 20 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (96% lower). The trial reports 12 study locations across 4 states.

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The verdict

NCT07150091, a Phase 1 study of Multiple Myeloma, is active but no longer recruiting, sponsored by GlaxoSmithKline.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
20 participants
Enrollment target
12
Study locations

Study Summary

The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with nirogacestat, lenalidomide, and dexamethasone, and to establish the recommended Phase 2 dose for combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. This study is a sub study of the Master protocol (NCT04126200).

Conditions Studied

Multiple Myeloma

Interventions

  • DRUG Belantamab mafodotin
  • DRUG Dexamethasone
  • DRUG Lenalidomide
  • DRUG Nirogacestat

Study Locations (12)

Other

  • GSK Investigational Site - São Paulo
  • GSK Investigational Site - Villejuif
  • GSK Investigational Site - Hamburg
  • GSK Investigational Site - Athens
  • GSK Investigational Site - Mexico City
  • GSK Investigational Site - Seoul
  • GSK Investigational Site - Seoul
  • GSK Investigational Site - Seoul
  • GSK Investigational Site - Ulsan

Massachusetts

  • GSK Investigational Site - Boston

Estado de Bahia

  • GSK Investigational Site - Salvador

Nova Scotia

  • GSK Investigational Site - Halifax

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2022-07-19
Est. Completion 2027-03-11
Phase Phase 1

Sponsor

GlaxoSmithKline

1,345 total trials

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What the Registry Record Tells You About NCT07150091

The ClinicalTrials.gov registry entry for NCT07150091 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (96% lower). The listed sponsor is GlaxoSmithKline, which has 1,345 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions - of which Belantamab mafodotin is the first listed.

NCT07150091 reports 12 study locations spanning 4 distinct geographic areas - top geographies include Other, Massachusetts, Estado de Bahia.

Frequently Asked Questions

What is clinical trial NCT07150091 about?

NCT07150091 is a clinical study titled "Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat, Lenalidomide, and Dexamethasone in Participants With RRMM". The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with nirogacestat, lenalidomide, and dexamethasone, and to establish the recommended Phase 2 dose for combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. ...

What is the current status of trial NCT07150091?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2022-07-19. Estimated completion is 2027-03-11.

What conditions does trial NCT07150091 study?

This clinical trial studies the following conditions: Multiple Myeloma.

What interventions are being tested in trial NCT07150091?

The interventions under investigation include: Belantamab mafodotin (DRUG), Dexamethasone (DRUG), Lenalidomide (DRUG), Nirogacestat (DRUG).

Who is sponsoring clinical trial NCT07150091?

This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07150091 being conducted?

This trial has 12 study locations across Massachusetts, Estado de Bahia, Nova Scotia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.