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A Study of MB-CART19.1 Cellular Therapy for People With Central Nervous System Lymphoma (CNSL)
NCT07137494 · View on ClinicalTrials.gov ↗
Study Summary
This study will test whether MB-CART19.1 is a safe and effective treatment for central nervous system lymphoma (CNSL). This study will test different doses of MB-CART19.1 to find the highest dose that causes few or mild side effects in participants.
Conditions Studied
Interventions
- BIOLOGICAL MB-CART19.1 Cellular Therapy
Study Locations (7)
New York
- Memorial Sloan Kettering at Suffolk-Commack (Limited Protocol Activities) — Commack
- Memorial Sloan Kettering at Westchester (Limited Protocol Activities) — Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York
- Memorial Sloan Kettering at Nassau (Limited Protocol Activities) — Uniondale
New Jersey
- Memorial Sloan Kettering at Basking Ridge (All Protocol Activities) — Basking Ridge
- Memorial Sloan Kettering at Monmouth (Limited Protocol Activities) — Middletown
- Memorial Sloan Kettering at Bergen (Limited Protocol Activities) — Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2025-08-14 |
| Est. Completion | 2028-08 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07137494
The ClinicalTrials.gov registry entry for NCT07137494 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Memorial Sloan Kettering Cancer Center, which has 2,280 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Secondary Central Nervous System Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which MB-CART19.1 Cellular Therapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07137494 reports 7 study locations spanning 2 distinct geographic areas — top geographies include New York, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07137494 about?
NCT07137494 is a clinical study titled "A Study of MB-CART19.1 Cellular Therapy for People With Central Nervous System Lymphoma (CNSL)". This study will test whether MB-CART19.1 is a safe and effective treatment for central nervous system lymphoma (CNSL). This study will test different doses of MB-CART19.1 to find the highest dose that causes few or mild side effects in participants.
What is the current status of trial NCT07137494?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2025-08-14. Estimated completion is 2028-08.
What conditions does trial NCT07137494 study?
This clinical trial studies the following conditions: Secondary Central Nervous System Lymphoma, Primary Central Nervous System (CNS) Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07137494?
The interventions under investigation include: MB-CART19.1 Cellular Therapy (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07137494?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 2,280 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07137494 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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